{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T02:58:33Z","timestamp":1792897113545,"version":"4.5.0"},"reference-count":145,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,1,17]],"date-time":"2022-01-17T00:00:00Z","timestamp":1642377600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Fundamemntal Clinical Pharma"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Being the most essential organ in the body, the liver performs critical functions. Hepatic disorders, such as alcoholic liver disease, hepatic steatosis, liver fibrosis, nonalcoholic fatty liver disease, hepatocellular carcinoma, and hepatic failure, have an impact on the biochemical and physiological functions of the body. The main representative of the flavonoid subgroup of flavones, resveratrol (RES), exhibits suitable pharmacological activities for treating various liver diseases, such as fatty hepatitis, liver steatosis, liver cancer, and liver fibrosis. According to various studies, grapes and red wine are good sources of RES. RES has various health properties; it is anti\u2010inflammatory, anti\u2010apoptotic, antioxidative, and hepatoprotective against several hepatic diseases and hepatoxicity. Therefore, we performed a thorough research and created a summary of the distinct targets of RES in various stages of liver diseases. We concluded that RES inhibited liver inflammation essentially by causing a significant decrease in the expression of various pro\u2010inflammatory cytokines like TNF\u2010\u03b1, IL\u20101\u03b1, IL\u20101\u03b2, and IL\u20106. It also inhibits the transcription factor nuclear NF\u2010\u03baB that brings about the inflammatory cascade. RES also inhibits the PI3K\/Akt\/mTOR pathway to induce apoptosis. Additionally, it reduces oxidative stress in hepatic tissue by markedly reducing malondialdehyde (MDA) and nitric oxide (NO) contents and significantly increasing the levels of catalase (CAT), superoxide dismutase (SOD), and reduced hepatic glutathione (GSH), in addition to aspartate aminotransferase (AST) and alanine aminotransferase (ALT), against toxic chemicals like CC14, As2O3, and TTA. Due to its antioxidant, anti\u2010inflammatory, and anti\u2010fibrotic properties, RES reduces liver injury markers. RES is safe natural antioxidant that provides pharmacological rectification of the hepatoxicity of toxic chemicals.<\/jats:p>","DOI":"10.1111\/fcp.12746","type":"journal-article","created":{"date-parts":[[2021,12,21]],"date-time":"2021-12-21T20:57:50Z","timestamp":1640120270000},"page":"468-485","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":73,"title":["Hepatoprotective and therapeutic effects of resveratrol: A focus on anti\u2010inflammatory and antioxidative activities"],"prefix":"10.1111","volume":"36","author":[{"given":"Supat","family":"Chupradit","sequence":"first","affiliation":[{"name":"Department of Occupational Therapy, Faculty of Associated Medical Sciences Chiang Mai University Chiang Mai Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dmitry","family":"Bokov","sequence":"additional","affiliation":[{"name":"Institute of Pharmacy Sechenov First Moscow State Medical University Moscow Russian Federation"},{"name":"Laboratory of Food Chemistry Federal Research Center of Nutrition, Biotechnology and Food Safety Moscow Russian Federation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0944-0320","authenticated-orcid":false,"given":"Mohammad Yassin","family":"Zamanian","sequence":"additional","affiliation":[{"name":"Department of Physiology, School of Medicine Hamedan University of Medical Sciences Hamadan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9814-9297","authenticated-orcid":false,"given":"Mahsa","family":"Heidari","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Institute of Biochemistry and Biophysics (IBB) University of Tehran Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elham","family":"Hakimizadeh","sequence":"additional","affiliation":[{"name":"Physiology\u2010Pharmacology Research Center, Research Institute of Basic Medical Sciences Rafsanjan University of Medical Sciences Rafsanjan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,1,17]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.6641"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jat.1310"},{"issue":"14","key":"e_1_2_14_4_1","first-page":"1","article-title":"National vital statistics reports","volume":"57","author":"Heron M","year":"2009","journal-title":"Natl Vital Stat Rep"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2017.08.005"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2019.108600"},{"key":"e_1_2_14_7_1","first-page":"116","article-title":"Hepatoprotective activity of methanol extract of some medicinal plants against carbon tetrachloride induced hepatotoxicity in albino rats","volume":"3","author":"Ahsan R","year":"2009","journal-title":"Glob J Pharmacol"},{"key":"e_1_2_14_8_1","article-title":"Network pharmacology study of the hepatoprotective effects of quercetin\u2010containing traditional chinese medicine, anoectochilus roxburghii, and validation of quercetin as an anti\u2010liver injury agent in a mouse model of liver injury","volume":"26","author":"Lin W","year":"2020","journal-title":"Med Sci Monitor: Int Med J Exp Clin Res"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18030620"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40199-020-00344-x"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijpvm.IJPVM_144_16"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psj.2019.10.009"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2021.130525"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-021-02099-0"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.4103\/1735-1995.168405"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.4067\/S0717-95022017000401342"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.104.000885"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/837042"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12082435"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/fcp.12280"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2016.11.057"},{"issue":"3","key":"e_1_2_14_22_1","first-page":"212","article-title":"Resveratrol attenuates malathion\u2010induced liver damage by reducing oxidative stress","volume":"11","author":"Jalili C","year":"2019","journal-title":"J Lab Phys"},{"key":"e_1_2_14_23_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408690490911701"},{"key":"e_1_2_14_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/jat.1393"},{"key":"e_1_2_14_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2010.02295.x"},{"key":"e_1_2_14_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hepres.2006.02.005"},{"key":"e_1_2_14_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/alcalc\/agh256"},{"key":"e_1_2_14_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/jat.1249"},{"issue":"6","key":"e_1_2_14_29_1","first-page":"1","article-title":"The protective effect of resveratrol against cyclosporine A\u2010induced oxidative stress and hepatotoxicity","volume":"127","author":"Bingul I","year":"2019","journal-title":"Arch Physiol Biochem"},{"key":"e_1_2_14_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3623"},{"key":"e_1_2_14_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/jhbp.245"},{"key":"e_1_2_14_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2017.11.003"},{"key":"e_1_2_14_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2016.06.018"},{"key":"e_1_2_14_34_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijp.IJP_299_16"},{"key":"e_1_2_14_35_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu13030933"},{"key":"e_1_2_14_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2014.07.007"},{"key":"e_1_2_14_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2018.08.062"},{"key":"e_1_2_14_38_1","doi-asserted-by":"publisher","DOI":"10.3322\/canjclin.55.2.74"},{"key":"e_1_2_14_39_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40104-018-0248-y"},{"key":"e_1_2_14_40_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18122589"},{"key":"e_1_2_14_41_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.14.7101"},{"key":"e_1_2_14_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2005.10.044"},{"key":"e_1_2_14_43_1","doi-asserted-by":"publisher","DOI":"10.2174\/138920112798868575"},{"key":"e_1_2_14_44_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25184282"},{"key":"e_1_2_14_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2006.09.010"},{"key":"e_1_2_14_46_1","first-page":"619","volume-title":"Understanding Pathways of Calorie Restriction: A Way to Prevent Cancer?","author":"Grifantini K","year":"2008"},{"key":"e_1_2_14_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(10)63726-2"},{"key":"e_1_2_14_48_1","doi-asserted-by":"publisher","DOI":"10.1158\/1940-6207.CAPR-09-0171"},{"key":"e_1_2_14_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-010-0144-4"},{"key":"e_1_2_14_50_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.14.4120"},{"key":"e_1_2_14_51_1","first-page":"24","article-title":"Metabolic syndrome: nonalcoholic fatty liver disease","volume":"435","author":"Williams T","year":"2015","journal-title":"FP Essent"},{"key":"e_1_2_14_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(01)00151-9"},{"key":"e_1_2_14_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.25762"},{"key":"e_1_2_14_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2015.3"},{"key":"e_1_2_14_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2006.10.014"},{"key":"e_1_2_14_56_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2018.06.083"},{"key":"e_1_2_14_57_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.05.060"},{"key":"e_1_2_14_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2019.108260"},{"key":"e_1_2_14_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2020.108363"},{"key":"e_1_2_14_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2015.03.005"},{"key":"e_1_2_14_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2012.10.026"},{"key":"e_1_2_14_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2020.108400"},{"key":"e_1_2_14_63_1","doi-asserted-by":"publisher","DOI":"10.1159\/000495898"},{"key":"e_1_2_14_64_1","doi-asserted-by":"publisher","DOI":"10.1139\/cjpp-2017-0001"},{"key":"e_1_2_14_65_1","doi-asserted-by":"publisher","DOI":"10.1186\/1743-7075-11-35"},{"key":"e_1_2_14_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2012.06.019"},{"key":"e_1_2_14_67_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.115.122937"},{"key":"e_1_2_14_68_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-8-40"},{"key":"e_1_2_14_69_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12944-015-0139-6"},{"key":"e_1_2_14_70_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2013.155"},{"key":"e_1_2_14_71_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox9050410"},{"key":"e_1_2_14_72_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24071297"},{"key":"e_1_2_14_73_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201500016"},{"key":"e_1_2_14_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2013.11.016"},{"key":"e_1_2_14_75_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep22251"},{"key":"e_1_2_14_76_1","doi-asserted-by":"publisher","DOI":"10.1080\/13813455.2018.1441872"},{"key":"e_1_2_14_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nutres.2014.09.005"},{"key":"e_1_2_14_78_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-016-2807-x"},{"key":"e_1_2_14_79_1","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2014.119"},{"key":"e_1_2_14_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)41965-0"},{"key":"e_1_2_14_81_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-2197.1980.tb04173.x"},{"key":"e_1_2_14_82_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510260116"},{"key":"e_1_2_14_83_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201100374"},{"key":"e_1_2_14_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2005.01.024"},{"key":"e_1_2_14_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2011.08.005"},{"key":"e_1_2_14_86_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-5491.2000.00259.x"},{"key":"e_1_2_14_87_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.2009.28822"},{"key":"e_1_2_14_88_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114511000316"},{"key":"e_1_2_14_89_1","doi-asserted-by":"publisher","DOI":"10.1177\/1479164113520332"},{"key":"e_1_2_14_90_1","doi-asserted-by":"publisher","DOI":"10.3109\/09637486.2014.1003534"},{"key":"e_1_2_14_91_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP278082"},{"key":"e_1_2_14_92_1","doi-asserted-by":"publisher","DOI":"10.1111\/dme.12231"},{"key":"e_1_2_14_93_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12010161"},{"key":"e_1_2_14_94_1","doi-asserted-by":"publisher","DOI":"10.1002\/0471141755.ph0547s70"},{"key":"e_1_2_14_95_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2016.00360"},{"key":"e_1_2_14_96_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00487.2005"},{"key":"e_1_2_14_97_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0124968"},{"key":"e_1_2_14_98_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.5501"},{"key":"e_1_2_14_99_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/703676"},{"key":"e_1_2_14_100_1","doi-asserted-by":"publisher","DOI":"10.1201\/9780367812041-9"},{"key":"e_1_2_14_101_1","doi-asserted-by":"publisher","DOI":"10.1002\/jat.1260"},{"key":"e_1_2_14_102_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2008.05598.x"},{"key":"e_1_2_14_103_1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.111.043539"},{"key":"e_1_2_14_104_1","first-page":"34","article-title":"Amelioration of cisplatin\u2010induced liver toxicity through antioxidative properties of hydroalcoholic extract of pistachio nuts in mice","volume":"2","author":"Hakimizadeh E","year":"2019","journal-title":"Pistachio Health J"},{"key":"e_1_2_14_105_1","doi-asserted-by":"publisher","DOI":"10.4103\/2231-4040.184594"},{"key":"e_1_2_14_106_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-11-283598"},{"key":"e_1_2_14_107_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/617202"},{"key":"e_1_2_14_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2012.09.023"},{"key":"e_1_2_14_109_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/506390"},{"key":"e_1_2_14_110_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0183426"},{"key":"e_1_2_14_111_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v13.i37.4955"},{"key":"e_1_2_14_112_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23258"},{"key":"e_1_2_14_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2013.09.014"},{"key":"e_1_2_14_114_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2016.3077"},{"key":"e_1_2_14_115_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-6-35"},{"key":"e_1_2_14_116_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2006.11.044"},{"key":"e_1_2_14_117_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/4287890"},{"key":"e_1_2_14_118_1","doi-asserted-by":"publisher","DOI":"10.1080\/01913123.2017.1374313"},{"key":"e_1_2_14_119_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2015.04.014"},{"key":"e_1_2_14_120_1","doi-asserted-by":"publisher","DOI":"10.1080\/01480545.2021.1908716"},{"key":"e_1_2_14_121_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/9396425"},{"issue":"3","key":"e_1_2_14_122_1","first-page":"218","article-title":"A quantitative study on the protective effects of resveratrol against bisphenol A\u2010induced hepatotoxicity in rats: a stereological study","volume":"46","author":"Bordbar H","year":"2021","journal-title":"Iran J Med Sci"},{"key":"e_1_2_14_123_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.12954"},{"key":"e_1_2_14_124_1","doi-asserted-by":"publisher","DOI":"10.1021\/np5003143"},{"key":"e_1_2_14_125_1","doi-asserted-by":"publisher","DOI":"10.1177\/0960327112468178"},{"key":"e_1_2_14_126_1","doi-asserted-by":"publisher","DOI":"10.1080\/00015458.2018.1455418"},{"key":"e_1_2_14_127_1","doi-asserted-by":"publisher","DOI":"10.5483\/BMBRep.2018.51.9.114"},{"key":"e_1_2_14_128_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2008.02.004"},{"key":"e_1_2_14_129_1","doi-asserted-by":"publisher","DOI":"10.1159\/000103658"},{"key":"e_1_2_14_130_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2008.06.012"},{"key":"e_1_2_14_131_1","doi-asserted-by":"publisher","DOI":"10.5152\/balkanmedj.2016.15516"},{"key":"e_1_2_14_132_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199808150-00005"},{"key":"e_1_2_14_133_1","doi-asserted-by":"publisher","DOI":"10.1002\/jlb.52.4.377"},{"key":"e_1_2_14_134_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.07.023"},{"key":"e_1_2_14_135_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20217"},{"key":"e_1_2_14_136_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2007.11.021"},{"key":"e_1_2_14_137_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2014\/719050","article-title":"Polycystic ovary syndrome, insulin resistance, and obesity: navigating the pathophysiologic labyrinth","volume":"2014","author":"Rojas J","year":"2014","journal-title":"Int J Reprod Med"},{"issue":"3","key":"e_1_2_14_138_1","doi-asserted-by":"crossref","first-page":"149","DOI":"10.29252\/ijrm.16.3.149","article-title":"The effect of resveratrol on oxidative stress in the liver and serum of a rat model of polycystic ovary syndrome: an experimental study","volume":"16","author":"Ghowsi M","year":"2018","journal-title":"Int J Reprod BioMed"},{"key":"e_1_2_14_139_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201400564"},{"key":"e_1_2_14_140_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/6781872"},{"key":"e_1_2_14_141_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2018.02910"},{"key":"e_1_2_14_142_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2014.05.011"},{"key":"e_1_2_14_143_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2021.104800"},{"key":"e_1_2_14_144_1","doi-asserted-by":"publisher","DOI":"10.3109\/15376516.2010.550016"},{"key":"e_1_2_14_145_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2009.3074"},{"key":"e_1_2_14_146_1","doi-asserted-by":"publisher","DOI":"10.1177\/0960327110383625"}],"container-title":["Fundamental &amp; Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/fcp.12746","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/fcp.12746","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/fcp.12746","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,14]],"date-time":"2024-09-14T20:01:59Z","timestamp":1726344119000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/fcp.12746"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,17]]},"references-count":145,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["10.1111\/fcp.12746"],"URL":"https:\/\/doi.org\/10.1111\/fcp.12746","archive":["Portico"],"relation":{},"ISSN":["0767-3981","1472-8206"],"issn-type":[{"value":"0767-3981","type":"print"},{"value":"1472-8206","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,17]]},"assertion":[{"value":"2021-09-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}