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The reactions of isothiocyanate with phosphinimine bestow thiaziridine, carbamate, and thiourea derivatives. Moreover, isothiocyanate reacts with tris (dimethylamino) phosphine leading to the formation of sulfidomethyl phosphonium. Lawesson's and Japanese reagents have potential to react with isothiocyanates to generate dithiaphosphetane sulfides. Treatment of isocyanate with Lawesson<jats:sup>'<\/jats:sup>s or Japanese reagents under reflux conditions affords thiaphosphetidinone sulfide, but when applied at room temperature, the dithiaphosphetane sulfide was isolated. Ehrlich ascites carcinoma (EAC) mice model was used to investigate potential anticancer properties of the novel phosphonium and thiophosphate derivatives. Synthesized compounds (100\u2009mg\/kg b.w.) were administered orally to the EAC\u2010bearing mice for about 2\u00a0weeks. Compounds' antineoplastic activity was determined by the evaluation of volume, viability, and inhibition percent of EAC cells. In addition, DNA fragmentation percent was assessed. The expression of apoptotic marker genes (Bax, Bcl2, Caspase 3) and encoding proinflammatory cytokines (TNF\u2010\u03b1) and pro\u2010apoptotic protein (p53) were inspected by real time\u2010quantitative polymerase chain reaction (RT\u2010qPCR). The overall conclusion was based on the findings that treatment with synthesized compounds leads to decrease in tumor volume, increase in tissue DNA fragmentation, downregulation of Bcl2 gene, and upregulation of Bax, caspase3, and p53 markers, along with decrease in TNF\u2010\u03b1 level in liver tissues. These findings suggest that the anticancer mechanism of these compounds is based on the programmed cell death (Apoptosis).<\/jats:p>","DOI":"10.1111\/fcp.12751","type":"journal-article","created":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T06:14:14Z","timestamp":1641363254000},"page":"536-552","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The synthesis and antineoplastic activities of thiaziridine, sulfidometylphosphonium, and dithiaphosphitane\u2010sulfide against the Ehrlich ascites carcinoma"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7562-6193","authenticated-orcid":false,"given":"Shaimaa T.","family":"Mansour","sequence":"first","affiliation":[{"name":"Organometallic and Organometalloid Chemistry Department National Research Centre  Giza Dokki Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed 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