{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:58:04Z","timestamp":1787507884723,"version":"build-2736575974"},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,1,20]],"date-time":"2022-01-20T00:00:00Z","timestamp":1642636800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Fundamemntal Clinical Pharma"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Nonsteroidal anti\u2010inflammatory drugs (NSAIDs) are among the best therapeutic options to treat pain. Their use in combination with other drugs may broaden their applicability in analgesia if their ceiling and adverse effects are reduced. The aim of this study was to evaluate the pharmacological interaction of two NSAIDs, paracetamol and meloxicam, with the antipsychotic drug risperidone in mice, in several experimental tests of nociceptive and inflammatory pain. Antinociception was assessed by dose\u2013response curves to paracetamol and meloxicam before and after the i.p. administration of 0.5\u2009mg\/kg of risperidone. Results are presented as means\u2009\u00b1\u2009SEM and differences were calculated by one\u2010way ANOVA followed by Tukey's post\u2010test. Paracetamol and meloxicam produced a dose\u2010related antinociceptive effect with diverse potencies. Risperidone increased the analgesia mediated by paracetamol and meloxicam only in the tonic tests that detected inflammatory pain. This suggests that COX inhibition is only a partial explanation of the increased analgesic potency of paracetamol and meloxicam since the effects of NSAIDs in the CNS are mediated by multiple mechanisms. These results indicate that the combination of risperidone with paracetamol or meloxicam could be a new and effective alternative for the management of inflammatory pain.<\/jats:p>","DOI":"10.1111\/fcp.12754","type":"journal-article","created":{"date-parts":[[2022,1,6]],"date-time":"2022-01-06T06:25:54Z","timestamp":1641450354000},"page":"494-500","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Risperidone in analgesia induced by paracetamol and meloxicam in experimental pain"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5199-1719","authenticated-orcid":false,"given":"Hugo F.","family":"Miranda","sequence":"first","affiliation":[{"name":"Neuroscience Department, Faculty of Medicine University of Chile  Santiago 8380000 Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viviana","family":"Noriega","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, German Cinic University of Development  Santiago 8380000 Chile"},{"name":"Cardiovascular Department University of Chile Clinical Hospital  Santiago 8380000 Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Sierralta","sequence":"additional","affiliation":[{"name":"Pharmacology Program, ICBM, Faculty of Medicine University of Chile  Santiago 8380000 Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ram\u00f3n","family":"Sotomayor\u2010Z\u00e1rate","sequence":"additional","affiliation":[{"name":"Laboratory of Neurochemistry and Neuropharmacology, Faculty of Sciences University of Valpara\u00edso  Valpara\u00edso 8380000 Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Carlos","family":"Prieto","sequence":"additional","affiliation":[{"name":"Cardiovascular Department University of Chile Clinical Hospital  Santiago 8380000 Chile"},{"name":"Pharmacology Program, ICBM, Faculty of Medicine University of Chile  Santiago 8380000 Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,1,20]]},"reference":[{"key":"e_1_2_12_2_1","first-page":"116","article-title":"Effect of nonsteroidal anti\u2010inflammatory drugs at the molecular level","volume":"50","author":"Gunaydin C","year":"2018","journal-title":"Eur J Med"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.2147\/JPR.S75160"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2710.2009.01143.x"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10571-020-01001-2"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-0956-673"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12929-014-0062-6"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1213\/00000539-200108000-00039"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ddr.21519"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-019-00664-8"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10571-019-00666-8"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2016.12.008"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21124355"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.36076\/ppj.2009\/12\/269"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1185\/03007995.2011.614934"},{"key":"e_1_2_12_16_1","first-page":"422","article-title":"Cyclooxigenase inhibitors from pharmacology to clinical read\u2010outs","volume":"2015","author":"Patrignani P","year":"1851","journal-title":"Biochim Biophys Acta"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2015.03.004"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-016-1263-1"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.molpharmaceut.8b00532"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1515\/jbcpp\u20102019\u20100332"},{"key":"e_1_2_12_21_1","first-page":"1328","article-title":"Effect of doxycycline and meloxicam on cytokines, brain\u2010derived neurotrophic factor, matrix metalloproteinase\u20103, tissue inhibitor of metalloproteinase\u20103 and cyclooxygenase\u20102 in brain","volume":"23","author":"Er A","year":"2020","journal-title":"Iran Basic Med Sci"}],"container-title":["Fundamental &amp; Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/fcp.12754","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/fcp.12754","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/fcp.12754","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T14:03:46Z","timestamp":1692972226000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/fcp.12754"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,20]]},"references-count":20,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["10.1111\/fcp.12754"],"URL":"https:\/\/doi.org\/10.1111\/fcp.12754","archive":["Portico"],"relation":{},"ISSN":["0767-3981","1472-8206"],"issn-type":[{"value":"0767-3981","type":"print"},{"value":"1472-8206","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,20]]},"assertion":[{"value":"2021-09-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}