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Andrographolide is generally considered an essential bioactive component of plant <jats:styled-content style=\"fixed-case\"><jats:italic>A<\/jats:italic>. <jats:italic>paniculata<\/jats:italic><\/jats:styled-content>. Since ancient times, it has been widely recognized for its therapeutic qualities and has attracted the scientific and medical communities' attention. This review summarizes the molecular, clinical, and <jats:italic>in vitro<\/jats:italic> research of compound andrographolide and its mechanism of action. Andrographolide, when combined with other enhancing agents, offers a wide variety of health benefits. The therapeutic potential of andrographolide has been exemplified and exhibited by directly regulating genes and indirectly interacting with small molecules and different enzymes. 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