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In the present study, we evaluated the protective effects of oral administration of CaD against hepatorenal damages in a mice model of aging induced by <jats:sc>d<\/jats:sc>\u2010galactose (<jats:sc>d<\/jats:sc>\u2010gal). We used 28 male albino mice, which equally and randomly were divided into four groups as follows: intact, aging (<jats:sc>d<\/jats:sc>\u2010gal at the dose of 500\u2009mg\/kg, p.o.), aging\u2009+\u2009CaD 50 (<jats:sc>d<\/jats:sc>\u2010gal plus CaD at the dose of 50\u2009mg\/kg), and aging\u2009+\u2009CaD 100 (<jats:sc>d<\/jats:sc>\u2010gal plus CaD at the dose of 100\u2009mg\/kg, p.o.). All drugs were administered orally once a day for 42\u2009days. The liver and kidney damages were evaluated by measuring mass indices, levels of serum creatinine and blood urea nitrogen, and activities of serum alanine aminotransferase, aspartate aminotransferase, and alkaline phosphatase and by histopathological evaluation. Moreover, hepatic and renal tissue oxidant\/antioxidant markers (malondialdehyde, superoxide dismutase, catalase, and glutathione peroxidase) were measured. The results showed that <jats:sc>d<\/jats:sc>\u2010gal treatment induced significant oxidative stress in the kidney and liver that was paralleled by dysfunctions and histological alterations of these organs. CaD significantly improved the liver and kidney indices, implemented functional capacity of the liver and kidney, as well as decreased oxidative stress enhancing antioxidative enzyme activities. CaD treatment also inhibited the development of histological alterations of both kidney and liver. CaD might represent a promising therapeutic agent for the attenuation of hepatorenal injuries induced by aging.<\/jats:p>","DOI":"10.1111\/fcp.12766","type":"journal-article","created":{"date-parts":[[2022,2,3]],"date-time":"2022-02-03T03:18:53Z","timestamp":1643858333000},"page":"721-730","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Calcium dobesilate protects against <scp>d<\/scp>\u2010galactose\u2010induced hepatic and renal dysfunction, oxidative stress, and pathological damage"],"prefix":"10.1111","volume":"36","author":[{"given":"Elham","family":"Hakimizadeh","sequence":"first","affiliation":[{"name":"Physiology\u2010Pharmacology Research Center, Research Institute of Basic Medical Sciences Rafsanjan University of Medical Sciences  Rafsanjan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0944-0320","authenticated-orcid":false,"given":"Mohammad 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