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The increasing prevalence of <jats:styled-content style=\"fixed-case\"><jats:italic>H.\u00a0pylori<\/jats:italic><\/jats:styled-content> infection and its related diseases, such as gastric cancer (GC), motivates medicinal chemists to seek for more effective multi\u2010targeting drugs to prevent and treat <jats:styled-content style=\"fixed-case\"><jats:italic>H.\u00a0pylori<\/jats:italic><\/jats:styled-content>\u2010related clinical complications. Benzimidazole, a hetero\u2010aromatic bicyclic ring compound, has claimed a prominent role in medicinal chemistry owing to its broad range of biological activities, including antibacterial, antiviral, antidiabetic, and anticancer activities. Studies highlight the promising therapeutic potential of benzimidazole derivatives in the treatment of <jats:styled-content style=\"fixed-case\"><jats:italic>H.\u00a0pylori<\/jats:italic><\/jats:styled-content>\u2010related clinical complications such as gastric infection, gastritis, peptic ulcer, and GC. Accordingly, we here aimed to scrutinize the role of active molecules of benzimidazole derivatives as potential antibacterial, anti\u2010urease, anti\u2010inflammatory, anti\u2010ulcerative, and anticancer agents, which are expected to find their ways to the clinical setting sooner or later. Due to the role of structural moieties in determining the biological behaviors of benzimidazole derivatives, we explored the structure\u2013activity relationship (SAR) of these compounds to further expand the scope of design of and research on new drugs against <jats:styled-content style=\"fixed-case\"><jats:italic>H.\u00a0pylori<\/jats:italic><\/jats:styled-content>\u2010related diseases.<\/jats:p>","DOI":"10.1111\/fcp.12810","type":"journal-article","created":{"date-parts":[[2022,6,18]],"date-time":"2022-06-18T17:04:26Z","timestamp":1655571866000},"page":"930-943","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Benzimidazole derivatives: A versatile scaffold for drug development against <scp><i>Helicobacter pylori<\/i><\/scp>\u2010related diseases"],"prefix":"10.1111","volume":"36","author":[{"given":"Hedieh","family":"Rostami","sequence":"first","affiliation":[{"name":"Department of Chemistry, Faculty of Basic 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