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N\u2010acetyl\u2010seryl\u2010aspartyl\u2010proline (Ac\u2010SDKP) and vasoactive intestinal peptide (VIP) as peptide have anti\u2010inflammatory effect, and, in this study, the effect of Ac\u2010SDKP and VIP on COPD inflammation was studied.<\/jats:p><jats:p>After producing cigarette smoke\u2010induced COPD mice model, which were treated with VIP and Ac\u2010SDKP, the levels of antioxidant\u2010related factors (malondialdehyde (MDA) and superoxide dismutase (SOD)), fibrotic factors (hydroxyproline (HP) and TGF\u2010\u03b2), pro\u2010inflammatory cytokines (TNF\u2010\u03b1, IL\u20101\u03b2, and IL\u20106), and inflammation in histopathological examination were studied.<\/jats:p><jats:p>MDA, Remodeling factors, pro\u2010inflammatory cytokines, and inflammation in lung tissue were controlled by VIP and Ac\u2010SDKP treatment. These treatments could enhance SOD.<\/jats:p><jats:p>VIP and Ac\u2010SDKP as immuno\u2010regulatory factors had benefit effect in treatment of COPD. The anti\u2010inflammatory, anti\u2010fibrosis, and anti\u2010oxidant properties of VIP and Ac\u2010SDKP may be effective therapy in COPD.<\/jats:p>","DOI":"10.1111\/fcp.12811","type":"journal-article","created":{"date-parts":[[2022,6,28]],"date-time":"2022-06-28T21:59:02Z","timestamp":1656453542000},"page":"1005-1010","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Immunomodulatory effect of N\u2010acetyl\u2010seryl\u2010aspartyl\u2010proline and vasoactive intestinal peptide on chronic obstructive pulmonary disease pathophysiology"],"prefix":"10.1111","volume":"36","author":[{"given":"Jian","family":"Cai","sequence":"first","affiliation":[{"name":"Department of Emergency The Second Hospital of Shandong University  Jinan City China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qianyi","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of General Surgery and Critical Care Unit Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine Chongming Brangch  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Entezar","family":"Mehrabi Nasab","sequence":"additional","affiliation":[{"name":"Department of Cardiology, School of Medicine, Tehran Heart Center Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6355-6378","authenticated-orcid":false,"given":"Seyyed Shamsadin","family":"Athari","sequence":"additional","affiliation":[{"name":"Department of Immunology, School of Medicine Zanjan University of Medical Sciences  Zanjan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,7,4]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2013.10.013"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2012.10.028"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004872\u2010200403000\u201000023"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00011\u2010018\u20101208\u2010x"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2007.04.009"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2016.10.014"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pupt.2010.03.008"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/cei.12289"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2010.10.008"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.2174\/156802606775270288"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2005.12.049"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00252.2015"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00424\u2010013\u20101262\u20108"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00252.2015"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00747.2008"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00305.2007"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000100423.24330.96"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2016.09.036"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00562.2015"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2018.07.006"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pupt.2006.06.006"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00562.2015"},{"issue":"3","key":"e_1_2_10_24_1","first-page":"25","article-title":"Prevalence of Linguatula serrata infection in domestic bovids slaughtered in Tabriz abattoir, Iran","volume":"4","author":"Hami M","year":"2009","journal-title":"Iran J Parasitol"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/fcp.12626"},{"issue":"1","key":"e_1_2_10_26_1","first-page":"54","article-title":"One\u2010humped camel (Camelus dromedarius) infestation with Linguatula serrata in Tabriz, Iran","volume":"4","author":"Haddadzadeh HR","year":"2010","journal-title":"Iran J Arthropod Borne Dis"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/fcp.12627"}],"container-title":["Fundamental &amp; 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