{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T02:38:07Z","timestamp":1791945487141,"version":"4.3.4"},"reference-count":17,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,7,22]],"date-time":"2022-07-22T00:00:00Z","timestamp":1658448000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Fundamemntal Clinical Pharma"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In France, the abuse\/misuse of psychoactive substances, including cocaine, is monitored via spontaneous notifications, and under\u2010reporting is its main limitation. Therefore, the French national hospital discharge database (<jats:italic>Programme de M\u00e9dicalisation des Syst\u00e8mes d'information<\/jats:italic> [PMSI]) was used to identify all hospital stays possibly due to complications related to cocaine use. The objective was to determine the main trends in the rate of cocaine\u2010related hospitalizations from 2010 to 2019 by age category and by areas. Relevant PMSI data were extracted using the International Classification of Diseases (10th edition). In France, hospitalizations for cocaine\u2010related complications increased by fourfold (2461 in 2010, 9843 in 2019, +300%). This increase was similar in men and women and was observed in each age category. Patients were mainly men (75% in 2010 and in 2019), with a median age of 38.5 and 35.2\u00a0years for men and women, respectively, in 2019. Cocaine poisoning in pediatric patients (0\u20139\u00a0years) concerned less than 10 patients in 2010 and 21 patients in 2019. PMSI data analysis shows an overall increase of cocaine\u2010related hospitalizations in France from 2010 to 2019 that can be linked in part to an increasing recreational use. The increase of pediatric cases of cocaine poisoning suggests a trivialization of cocaine consumption.<\/jats:p>","DOI":"10.1111\/fcp.12815","type":"journal-article","created":{"date-parts":[[2022,7,8]],"date-time":"2022-07-08T10:09:33Z","timestamp":1657274973000},"page":"1128-1132","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Ten\u2010year trends in hospitalizations related to cocaine abuse in France"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7839-9811","authenticated-orcid":false,"given":"C\u00e9line","family":"Eiden","sequence":"first","affiliation":[{"name":"Department of Medical Pharmacology and Toxicology Montpellier University Hospital  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Roy","sequence":"additional","affiliation":[{"name":"Department of Medical Pharmacology and Toxicology Montpellier University Hospital  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Malafaye","sequence":"additional","affiliation":[{"name":"Department of Medical data, Health Care Processes and Cost Analysis Unit Montpellier University Hospital  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Lehmann","sequence":"additional","affiliation":[{"name":"Department of Medical data, Health Care Processes and Cost Analysis Unit Montpellier University Hospital  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4735-9099","authenticated-orcid":false,"given":"H\u00e9l\u00e8ne","family":"Peyri\u00e8re","sequence":"additional","affiliation":[{"name":"Department of Medical Pharmacology and Toxicology Montpellier University Hospital  Montpellier France"},{"name":"Pathogenesis and Control of Chronic Infections, Univ Montpellier, INSERM, EFS, CHU Montpellier  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,7,22]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"EMCDDA.EMCDDA Drug Report 2020.https:\/\/www.emcdda.europa.eu\/edr2020(available September 2020)."},{"key":"e_1_2_10_3_1","first-page":"1","article-title":"Levels of illicit drug use in France in 2017","volume":"128","author":"Spilka S","year":"2018","journal-title":"Tendances"},{"key":"e_1_2_10_4_1","first-page":"1","article-title":"Drug use in 17\u2010year\u2010olds: analysis of the 2017 ESCAPAD survey","volume":"123","author":"Spilka S","year":"2018","journal-title":"Tendances"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.2515\/therapie\/2015011"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.therap.2019.09.005"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/fcp.12603"},{"key":"e_1_2_10_8_1","unstructured":"The French National Agency for the Safety of Medicines and Health Products (ANSM).Increased reports of cocaine and crack\u2010related intoxication\u2014security information.https:\/\/ansm.sante.fr\/actualites\/augmentation-des-signalements-dintoxication-liee-a-la-consommation-de-cocaine-et-de-crack(available 22\/07\/2021)."},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.3280"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.3369"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40261\u2010018\u20100679\u20104"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.2515\/therapie\/2013042"},{"key":"e_1_2_10_13_1","unstructured":"MR\u2010005.https:\/\/www.cnil.fr\/fr\/declaration\/mr-005-etudes-necessitant-lacces-aux-donnees-du-pmsi-etou-des-rpu-par-les-etablissements"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.3109\/15563650.2015.1088157"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/fcp.12233"},{"key":"e_1_2_10_16_1","unstructured":"ANSM.ANSM Actualit\u00e9\u2014Augmentation du nombre d'intoxications au cannabis par ingestion accidentelle chez les enfants\u2014ANSM (sante.fr) (available 25\/05\/2022)."},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyw359"},{"key":"e_1_2_10_18_1","unstructured":"World Health Organization.Alcohol drugs and addictive behaviours unit.https:\/\/www.who.int\/teams\/mental-health-and-substance-use\/alcohol-drugs-and-addictive-behaviours\/drugs-psychoactive(available 25\/05\/2022)."}],"container-title":["Fundamental &amp; Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/fcp.12815","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/fcp.12815","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/fcp.12815","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T12:36:53Z","timestamp":1692621413000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/fcp.12815"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,22]]},"references-count":17,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["10.1111\/fcp.12815"],"URL":"https:\/\/doi.org\/10.1111\/fcp.12815","archive":["Portico"],"relation":{},"ISSN":["0767-3981","1472-8206"],"issn-type":[{"value":"0767-3981","type":"print"},{"value":"1472-8206","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,22]]},"assertion":[{"value":"2022-02-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}