{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:18:57Z","timestamp":1787314737526,"version":"build-2736575974"},"reference-count":65,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,8,3]],"date-time":"2022-08-03T00:00:00Z","timestamp":1659484800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","award":["45\/34\u20102014\/PHA\u2010BMS"],"award-info":[{"award-number":["45\/34\u20102014\/PHA\u2010BMS"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Fundamemntal Clinical Pharma"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Nitric oxide (NO), generated by nitric oxide synthase enzymes (NOS), has an important role in maintaining synapse plasticity, neuro\u2010modulation, and other physiological functions in the brain. NO thus generated also has a key role in formation of reactive oxygen and reactive nitrite species and subsequent neuronal damage due to sustained oxidative stress. Due to its property of ROS and RNOS generation, NO plays a significant role in Parkinson's disease (PD) pathogenesis. Therefore, we evaluated the effect of mangiferin alone and in combination with nNOS inhibitor 7\u2010nitro\u2010indazole (7\u2010NI) in 6\u2010OHDA lesioned rats. Male Wistar rats weighing 200\u2013250\u2009g (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20098\/group) were used in the study. Stereotactic surgeries of rats were done to induce 6\u2010OHDA lesioning in rats. Then, treatment with mangiferin alone and in combination with 7\u2010NI 10\u00a0mg\/kg was done from days 14 to 42 for 28\u2009days. On day 42, rats were subjected to behavioral studies, and their brains were taken out after euthanasia to perform biochemical and molecular studies. Treatment with mangiferin and 7\u2010NI significantly increases locomotor parameters in 6\u2010OHDA lesioned rats. Treatment with mangiferin 45\u2009\u03bcg and 7\u2010NI 10\u00a0mg\/kg alone and in combination significantly reduces oxidative stress along with decrease in concentration of pro\u2010inflammatory cytokines, cyclooxygenase 2, total nitrite (NOx) and FOS B concentration. Results of this study suggest that treatment with 7\u2010NI 10\u00a0mg\/kg further enhances anti\u2010inflammatory and anti\u2010parkinsonism activity of mangiferin owing to its property of inhibiting nNOS mediated FOS B signaling and thereby inhibiting mRNA formation of TNF\u2010\u03b1 and IL\u20106.\n                  <\/jats:p>","DOI":"10.1111\/fcp.12817","type":"journal-article","created":{"date-parts":[[2022,7,19]],"date-time":"2022-07-19T20:28:28Z","timestamp":1658262508000},"page":"944-955","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Effects of mangiferin and its combination with nNOS inhibitor 7\u2010nitro\u2010indazole (7\u2010NI) in 6\u2010hydroxydopamine (6\u2010OHDA) lesioned Parkinson's disease rats"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7913-5386","authenticated-orcid":false,"given":"Prafulla Chandra","family":"Tiwari","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Therapeutics King George's Medical University  Lucknow Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4661-2243","authenticated-orcid":false,"given":"Manju J.","family":"Chaudhary","sequence":"additional","affiliation":[{"name":"Department of Physiology Government Medical College  Kannauj Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9813-6990","authenticated-orcid":false,"given":"Rishi","family":"Pal","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Therapeutics King George's Medical University  Lucknow Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3818-6720","authenticated-orcid":false,"given":"Rajendra","family":"Nath","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Therapeutics King George's Medical University  Lucknow Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,8,3]]},"reference":[{"issue":"11","key":"e_1_2_12_2_1","first-page":"5188","article-title":"Parkinson's disease\u2013a molecular approach","volume":"5","author":"Gautam RK","year":"2012","journal-title":"J Pharm Res"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.276.5321.2045"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2004.10.023"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1086\/380647"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-003-0108-0"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)68970-8"},{"issue":"8649","key":"e_1_2_12_8_1","first-page":"1215","article-title":"Mitochondrial complex I deficiency in Parkinson's disease","volume":"1","author":"Schapira AH","year":"1989","journal-title":"Lancet"},{"key":"e_1_2_12_9_1","first-page":"133","article-title":"Is the cause of Parkinson's disease environmental or hereditary? 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