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The protective effect of ferulic acid on diabetic cardiomyopathy in fructose\u2010streptozotocin induced type 2 diabetes (T2D) rat model was elucidated in this study. Type 2 diabetic rats were treated by oral administration of low (150\u2009mg\/kg b.w) and high (300\u2009mg\/kg b.w) doses of ferulic acid. Metformin was used as the antidiabetic drug. Rats were humanely euthanized after 5\u00a0weeks of treatment, and their blood and hearts were collected. Induction of T2D depleted the levels of reduced glutathione, glycogen, and HDL\u2010cholesterol and the activities of superoxide dismutase, catalase, ENTPDase, and 5\u2032nucleotidase. It simultaneously triggered increase in the levels of malondialdehyde, total cholesterol, triglyceride, LDL\u2010cholesterol, creatinine kinase\u2010MB as well as activities of acetylcholinesterase, angiotensin converting enzyme (ACE), ATPase, glucose\u20106\u2010phopsphatase, fructose\u20101,6\u2010bisphophatase, glycogen phosphorylase, and lipase. T2D induction further revealed an obvious degeneration of cardiac muscle morphology. However, treatment with ferulic acid markedly reversed the levels and activities of these biomarkers with concomitant improvement in myocardium structural morphology, which had favorable comparison with the standard drug, metformin. Additionally, T2D induction led to the depletion of 40%, 75%, and 33% of fatty acids, fatty esters, and steroids, respectively, with concomitant generation of eicosenoic acid, gamolenic acid, and vitamin E. Ferulic acid treatment restored eicosanoic acid, 2\u2010hydroxyethyl ester, with concomitant generation of 6\u2010octadecenoic acid, (Z)\u2010, cis\u201011\u2010eicosenoic acid, tridecanedioic acid, octadecanoic acid, 2\u2010hydroxyethyl ester, ethyl 3\u2010hydroxytridecanoate, dipalmitin, cholesterol isocaproate, cholest\u20105\u2010ene, 3\u2010(1\u2010oxobuthoxy)\u2010, cholesta\u20103,5\u2010diene. These results suggest the cardioprotective potential of ferulic acid against diabetic cardiomyopathy.<\/jats:p>","DOI":"10.1111\/fcp.12819","type":"journal-article","created":{"date-parts":[[2022,7,16]],"date-time":"2022-07-16T06:49:32Z","timestamp":1657954172000},"page":"44-59","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Ferulic acid mitigates diabetic cardiomyopathy via modulation of metabolic abnormalities in cardiac tissues of diabetic rats"],"prefix":"10.1111","volume":"37","author":[{"given":"Veronica F.","family":"Salau","sequence":"first","affiliation":[{"name":"Department of Biochemistry University of KwaZulu\u2010Natal  Durban South Africa"},{"name":"Department of Pharmacology University of the Free State  Bloemfontein South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0489-338X","authenticated-orcid":false,"given":"Ochuko L.","family":"Erukainure","sequence":"additional","affiliation":[{"name":"Department of Pharmacology University of the Free State  Bloemfontein South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kolawole A.","family":"Olofinsan","sequence":"additional","affiliation":[{"name":"Department of Biochemistry University of KwaZulu\u2010Natal  Durban South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nontokozo Z.","family":"Msomi","sequence":"additional","affiliation":[{"name":"Department of Biochemistry University of KwaZulu\u2010Natal  Durban South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olayemi K.","family":"Ijomone","sequence":"additional","affiliation":[{"name":"Department of Anatomy University of Medical Sciences  Ondo City Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. 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