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Bacteria have several drug resistance mechanisms, among them the efflux pump; this mechanism, when active, is able to expel different compounds from inside bacterial cells. Several efflux pumps have already been identified for <jats:styled-content style=\"fixed-case\"><jats:italic>Staphylococcus aureus<\/jats:italic><\/jats:styled-content> bacteria, including MepA and NorA. Many chalcones have been isolated and identified with various activities, such as antimicrobial. In view of this, this article aimed to evaluate the antibiotic modifying effect of chalcone (E)\u20101\u2010(2\u2010hydroxyphenyl)\u20103\u2010(3\u2010nitrophenyl)prop\u20102\u2010en\u20101\u2010one against <jats:styled-content style=\"fixed-case\"><jats:italic>S.\u00a0aureus<\/jats:italic><\/jats:styled-content> carrier of NorA and MepA efflux pump. Regarding the antibiotic, there was a synergism when associated with ciprofloxacin in SA\u2010K2068 strain, showing this chalcone as an alternative to reverse the resistance to this medicine. The physicochemical properties calculated were fundamental in the description of the predicted pharmacokinetic properties. Despite the mutagenic risk caused by the metabolic activation of nitrochalcone, it is possible to notice a pharmacological principle in a longer half\u2010life for the performance of biological activities. The compound has a good bioavailability, as it is highly absorbed in the intestine and easily transported by plasma proteins, in addition to not presenting neurotoxic, hepatotoxic, and cardiotoxic damage.<\/jats:p>","DOI":"10.1111\/fcp.12830","type":"journal-article","created":{"date-parts":[[2022,9,9]],"date-time":"2022-09-09T09:53:44Z","timestamp":1662717224000},"page":"163-173","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["ADMET study, spectroscopic characterization and effect of synthetic nitro chalcone in combination with norfloxacin, ciprofloxacin, and ethidium bromide against <scp><i>Staphylococcus aureus<\/i><\/scp> efflux pumps"],"prefix":"10.1111","volume":"37","author":[{"given":"Jana\u00edna E.","family":"Rocha","sequence":"first","affiliation":[{"name":"Departamento de Qu\u00edmica Biol\u00f3gica Universidade Regional do Cariri  Crato Cear\u00e1 Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thiago S.","family":"de Freitas","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Biol\u00f3gica Universidade Regional do Cariri  Crato Cear\u00e1 Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jayze C.","family":"Xavier","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Biol\u00f3gica Universidade Regional do Cariri  Crato Cear\u00e1 Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raimundo L. 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