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This study aimed to investigate the effect of ceftriaxone on intestinal transit time. Sixteen rats were examined in two groups: The study group (group A, <jats:italic>n<\/jats:italic>\u00a0=\u20098) was administered with 100\u2009mg\/kg ceftriaxone intramuscularly for 7\u00a0days. The control group (group B, <jats:italic>n<\/jats:italic>\u00a0=\u20098) was administered with intramuscular distilled water for 7\u00a0days. On the seventh day, a mixture of 2\u00a0ml barium and saline was given orally to both groups. Barium transit was evaluated using serial digital X\u2010ray images. The stomach was full and the transition into the small intestine loop was observed in all rats at 45\u2009min in both groups. At the 2nd hour, colonic transition was observed in two rats in group A (2\/8, 25%) and in seven rats in group B (7\/8, 87.5%). At the 4th hour, five (62.5%) rats in group A had transverse colonic transition, and all rats in group B (8\/8, 100%) had transverse and\/or left colonic transition. At the 6th hour, no rat in group A had rectal transition, and all rats in group B (8\/8, 100%) had complete passage of colonic contrast material. Ceftriaxone significantly prolongs the small intestine transit time, large intestine transit time, and total intestinal transit times.<\/jats:p>","DOI":"10.1111\/fcp.12841","type":"journal-article","created":{"date-parts":[[2022,10,8]],"date-time":"2022-10-08T15:49:27Z","timestamp":1665244167000},"page":"158-162","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effect of ceftriaxone on intestinal transit time"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7149-5627","authenticated-orcid":false,"given":"Mehmet","family":"Arpac\u0131k","sequence":"first","affiliation":[{"name":"Pediatric Surgery, Pediatric Burn Center Umraniye Training and Research Hospital  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeliha Ak\u0131\u015f","family":"Y\u0131ld\u0131z","sequence":"additional","affiliation":[{"name":"Pediatric Surgery Umraniye Training and Research Hospital  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,10,24]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics9040221"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm.2014.20.2.265"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1308\/rcsann.2019.0158"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620\u2010011\u20101755\u20102"},{"key":"e_1_2_8_6_1","first-page":"2356","volume-title":"Feigin and Cherry's textbook of pediatric infectious diseases","author":"Taylor RS","year":"2019"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.2147\/DHPS.S183892"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2004.05.020"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445\u20102197.2006.03922.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/fcp.12741"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306\u20103623(94)90015\u20109"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1R541"},{"key":"e_1_2_8_13_1","first-page":"201","article-title":"Interactions of fazadinium bromide with aminoglycoside antibiotics at neuromuscular junctions","volume":"4","author":"Pangalis A","year":"1991","journal-title":"J Chem"},{"issue":"3","key":"e_1_2_8_14_1","first-page":"199","article-title":"Gut mobility attenuation induced by antibiotics is associated with overactivation of enteric glial cells in mice","volume":"35","author":"Xie T","year":"2019","journal-title":"Chin J Cell Mol Immunol"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/fcp.12616"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.4166\/kjg.2014.63.6.378"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.14309\/crj.2014.40"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/fcp.12577"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dky553"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/00042737\u2010199702000\u201000018"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365\u20102036.2000.014s2009.x"}],"container-title":["Fundamental &amp; 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