{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:49:59Z","timestamp":1787014199819,"version":"build-2736575974"},"reference-count":53,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,11,16]],"date-time":"2022-11-16T00:00:00Z","timestamp":1668556800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Fundamemntal Clinical Pharma"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Resistance of malaria parasites to conventionally used antimalarial drugs has necessitated the search for new potent antimalarials, especially those that can also ameliorate oxidative stress\u2010mediated secondary complications. This has led to the synthesis of an antimalarial artesunate\u2013procyanidin hybrid compound (PC14), but it has not been evaluated for its antioxidant activity. This study was carried out to evaluate the antioxidant activities of PC14 in the erythrocyte and liver of\n                    <jats:italic>Plasmodium berghei<\/jats:italic>\n                    NK65\u2010infected mice. A hundred mice were randomly divided into 10 equal groups (A\u2013J). Mice in Groups B\u2013J were inoculated with\n                    <jats:italic>P.\u00a0berghei<\/jats:italic>\n                    NK65 while group A mice were not inoculated. Starting from Day 3 post\u2010inoculation, dimethyl sulfoxide (DMSO) (5%) was administered to mice in Groups A and B (normal and negative controls, respectively), while various doses of chloroquine, artesunate, procyanidin, and PC14 were administered to their respective groups for 3\u2009days. Thereafter, antioxidant parameters were determined in the erythrocyte and liver on Days 6 and 10 post\u2010inoculation. A significant increase (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.05) was observed in malondialdehyde levels in the erythrocyte and liver of negative control on Day 10 post\u2010inoculation compared to normal controls. Significant reduction (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.05) was observed in activities of liver catalase and superoxide dismutase and erythrocyte glutathione peroxidase and glutathione\u2010S\u2010transferase of negative control on Days 6 and 10 compared to normal controls. However, PC14 at various doses significantly (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.05) reversed these alterations. The results suggest that PC14 possesses antioxidant activity, and it enhanced antioxidant defense in the erythrocyte and liver of\n                    <jats:italic>P.\u00a0berghei<\/jats:italic>\n                    \u2010infected mice.\n                  <\/jats:p>","DOI":"10.1111\/fcp.12846","type":"journal-article","created":{"date-parts":[[2022,10,29]],"date-time":"2022-10-29T04:59:10Z","timestamp":1667019550000},"page":"305-315","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Antioxidant activities of artesunate\u2013procyanidin hybrid compound in erythrocyte and liver of\n                    <i>Plasmodium berghei<\/i>\n                    NK65\u2010infected mice"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5466-322X","authenticated-orcid":false,"given":"Habibu","family":"Tijjani","sequence":"first","affiliation":[{"name":"Department of Biochemistry, Faculty of Science Bauchi State University  Gadau Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3151-2247","authenticated-orcid":false,"given":"Joseph O.","family":"Adebayo","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Life Sciences University of Ilorin  Ilorin Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,11,16]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"WHO world malaria report.World Health Organization.2021. 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