{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:27:43Z","timestamp":1791228463330,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Fundamemntal Clinical Pharma"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The assessment of mood disorders and addiction linked to the practice of chemsex is of interest given the psychoactive substances used. The aim of this study was to assess risky sexual and addictive behavior to chemsex and related anxiety\/depression symptoms in individuals receiving HIV pre\u2010exposure prophylaxis (PrEP). In this cross\u2010sectional study, all adults presenting for PrEP renewal at French sexual health centers were enrolled from January 2018 to March 2019. Participants completed a questionnaire on chemsex (i.e., the use of psychoactive substances before\/during sex), including adapted Alcohol, Smoking and Substance Involvement Screening Test (ASSIST) to chemsex addiction (questions of ASSIST were modified to focus on chemsex). Anxiety\/depression was assessed with the Hospital Anxiety and Depression Scale. In the last 3\u2009months before enrollment, 39.8% (94\/236) of participants reported chemsex. The main psychoactive substances consumed during chemsex were cathinones (74.6%), gamma\u2010hydroxybutyrate (66.3%), and other psychostimulants (60%). The median score of the chemsex\u2010focused ASSIST was 8 [IQR<jats:sub>25\u201375<\/jats:sub>: 3\u201315]; 72.2% of participants had a score justifying at least a brief intervention (&gt;4). In multivariate analyses, anxiety and cathinones consumption were associated with an ASSIST score &gt;4: OR 13.65 (<jats:sub>95%<\/jats:sub>CI 1.68\u2013662.7), <jats:italic>P<\/jats:italic>\u2009=\u20090.0062, and OR 8.468 (<jats:sub>95%<\/jats:sub>CI 2.066\u201343.059), <jats:italic>P<\/jats:italic>\u2009=\u20090.0014, respectively. The level of addiction to the practice of chemsex can be difficult to estimate for the user, and the ASSIST makes it possible to evaluate this addiction and to direct the subjects toward specialized consultations of addictology, sexual health, or PrEP renewals. The implementation of the modified ASSIST in these consultations can allow early systematic screening and counseling.<\/jats:p>","DOI":"10.1111\/fcp.12854","type":"journal-article","created":{"date-parts":[[2022,11,20]],"date-time":"2022-11-20T10:59:25Z","timestamp":1668941965000},"page":"639-649","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Chemsex in HIV pre\u2010exposure prophylaxis users: Assessment of mood disorders and addictive behavior"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4735-9099","authenticated-orcid":false,"given":"H\u00e9l\u00e8ne","family":"Peyriere","sequence":"first","affiliation":[{"name":"INSERM U1175\/IRD UMI 233 Montpellier University  Montpellier France"},{"name":"Pathogenesis and Control of Chronic Infections University of Montpellier, INSERM, EFS, CHU Montpellier  Montpellier 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