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The antinociceptive effect was determined by assessing behavioural responses in different pain models, while anti\u2010inflammatory activity was examined in carrageenan\u2010induced pleurisy. Intraperitoneal LQM10 administration reduced the acetic acid\u2010induced nociceptive behaviour, a phenomenon that was unaltered by pretreatment with yohimbine, atropine, naloxone or glibenclamide. In the formalin assay, LQM10 reduced nociceptive behaviour only in the second phase, indicating an inhibitory effect on inflammatory pain. LQM10 did not alter the pain latency in the hot plate assay and did not impact the locomotor activity of mice in the rotarod assay. In the carrageenan\u2010induced pleurisy assay, LQM10 treatment inhibited critical events involved in inflammatory responses, namely, leucocyte recruitment, plasma leakage and increased inflammatory mediators (tumour necrosis factor Like Properties of Chalchones and Flavonoid Derivatives [TNF]\u2010\u03b1 and interleukin [IL]\u20101\u03b2) in the pleural exudate. Overall, these results indicate that LQM10 exhibits antinociceptive effects associated with peripheral mechanisms and anti\u2010inflammatory activity mediated via a reduction in leucocyte migration and proinflammatory mediators, rendering this compound a promising candidate for treating pain and inflammatory process.<\/jats:p>","DOI":"10.1111\/fcp.12862","type":"journal-article","created":{"date-parts":[[2022,12,29]],"date-time":"2022-12-29T11:57:51Z","timestamp":1672315071000},"page":"619-628","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["LQM10, a guanylhydrazone derivative, reduces nociceptive and inflammatory responses in mice"],"prefix":"10.1111","volume":"37","author":[{"given":"Jo\u00e3o Paulo","family":"No\u00e9","sequence":"first","affiliation":[{"name":"Laboratory of Cell Biology, Institute of Biological Sciences and Health Federal University of Alagoas  Macei\u00f3 57072\u2010970 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