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This agent also has anti\u2010inflammatory and antioxidant properties. The current study investigated the effects of GFZ on hepatorenal damages in a D\u2010galactose (D\u2010gal)\u2010induced aging model. We used 28 male mice, which were equally and randomly divided into four groups as follows: normal, D\u2010gal (150\u2009mg\/kg\/day; intraperitoneal [i.p.], for 6\u00a0weeks), GFZ (100\u2009mg\/kg\/day GFZ, orally [p.o.]\u00a0for 6\u2009weeks), and the combined D\u2010gal\u2009+\u2009GFZ. Liver and kidney function indices were measured as serum creatinine, blood urine nitrogen, alanine aminotransferase, and aspartate aminotransferase. Oxidative stress in hepatic and renal tissue was evaluated through malondialdehyde, superoxide dismutase, and glutathione peroxidase levels. Finally, the liver and kidney tissues were assessed for histopathological lesions. The results showed that D\u2010gal\u2010induced aging leads to abnormalities in liver and kidney function indices. D\u2010gal also induced significant oxidative stress and histopathological lesions in these organs. GFZ improved function indices and oxidative stress compared to the D\u2010gal\u2010treated animals. Histological evaluations of the liver and kidney also confirmed these results. These data provide evidence for the potential therapeutic of GFZ in clinical practice for mitigating the hepatorenal damages of aging.<\/jats:p>","DOI":"10.1111\/fcp.12865","type":"journal-article","created":{"date-parts":[[2023,1,5]],"date-time":"2023-01-05T05:59:10Z","timestamp":1672898350000},"page":"599-605","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Gemfibrozil, a lipid\u2010lowering drug, improves hepatorenal damages in a mouse model of aging"],"prefix":"10.1111","volume":"37","author":[{"given":"Elham","family":"Hakimizadeh","sequence":"first","affiliation":[{"name":"Physiology\u2010Pharmacology Research Center, Research Institute of Basic Medical Sciences Rafsanjan University of Medical Sciences  Rafsanjan Iran"},{"name":"Department of Physiology and Pharmacology, School of Medicine Rafsanjan University of Medical Sciences  Rafsanjan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saeedeh","family":"Tadayon","sequence":"additional","affiliation":[{"name":"Physiology\u2010Pharmacology Research Center, Research Institute of Basic Medical Sciences Rafsanjan University of Medical Sciences  Rafsanjan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0944-0320","authenticated-orcid":false,"given":"Mohammad Yasin","family":"Zamanian","sequence":"additional","affiliation":[{"name":"Department of Physiology, School of Medicine Hamadan University of Medical Sciences  Hamadan Iran"},{"name":"Department of Pharmacology and Toxicology, School of Pharmacy Hamadan University of Medical Sciences  Hamadan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afsaneh","family":"Soltani","sequence":"additional","affiliation":[{"name":"School of Medicine Iran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lydia","family":"Gim\u00e9nez\u2010Llort","sequence":"additional","affiliation":[{"name":"Institut de Neuroci\u00e8ncies &amp; 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