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Fetuin\u2010A has a variety of biological and pharmacological properties. The anti\u2010inflammatory and antioxidant glycoprotein fetuin\u2010A has shown its efficacy in a number of inflammatory disorders including sepsis. However, its protective role against sepsis\u2010induced myocardial injury remains elusive. The purpose of this work is to explore the role of fetuin\u2010A in mouse models of myocardial injury brought on by cecal ligation and puncture (CLP). CLP significantly induced the myocardial injury assessed in terms of elevated myocardial markers (serum CK\u2010MB, cTnI levels), inflammatory markers (IL\u20106, TNF\u2010\u03b1) in the serum, and oxidative stress markers (increased MDA levels and decreased reduced glutathione) in heart tissue homogenate following 24\u2009h of ligation and puncture. Further, hematoxylin and eosin (H&amp;E) staining showed considerable histological alterations in the myocardial tissue of sepsis\u2010developed mice. Interestingly, fetuin\u2010A pretreatment (50 and 100\u2009mg\/kg) for 4\u2009days before the CLP procedure significantly improved the myocardial injury and was evaluated in perspective of a reduction in the CK\u2010MB, cTnI levels, IL\u20106, and TNF\u2010\u03b1 in sepsis\u2010developed animals. Fetuin\u2010A pretreatment significantly attenuated the oxidative stress and improved the myocardial morphology in a dose\u2010dependent manner. The present study provides preliminary evidence that fetuin\u2010A exerts protection against sepsis\u2010induced cardiac dysfunction in vivo via suppression of inflammation and oxidative damage.<\/jats:p>","DOI":"10.1111\/fcp.12870","type":"journal-article","created":{"date-parts":[[2023,1,17]],"date-time":"2023-01-17T05:55:20Z","timestamp":1673934920000},"page":"607-617","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Exogenous fetuin\u2010A protects against sepsis\u2010induced myocardial injury by inhibiting oxidative stress and inflammation in mice"],"prefix":"10.1111","volume":"37","author":[{"given":"V","family":"Sidheeque Hassan","sequence":"first","affiliation":[{"name":"Department of Pharmacology Central University of Punjab  Bathinda India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohd","family":"Hanifa","sequence":"additional","affiliation":[{"name":"Department of Pharmacology 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