{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:09:01Z","timestamp":1747184941655,"version":"3.40.5"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,3,15]],"date-time":"2023-03-15T00:00:00Z","timestamp":1678838400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Fundamemntal Clinical Pharma"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Benzodiazepines (BZDs) are the first\u2010line treatment of alcohol withdrawal. Comorbidity between benzodiazepine use disorder (BUD) and alcohol use disorders (AUD) is common. However, the risk factors are poorly characterized due to the paucity of available BUD screening tools. The present study aimed to rectify this by conducting an observational screening investigation for BUD in patients hospitalized for alcohol detoxification in a specialized unit. During a face\u2010to\u2010face interview, a short BUD screening tool, <jats:italic>Echelle Cognitive d'Attachement aux benzodiaz\u00e9pines<\/jats:italic> (ECAB), was administered to record recent patterns of BZD use, thereby allowing categorization of AUD patients as follows: non\u2010BZD users, BZD users without BUD, and BUD (ECAB \u22656). Clinical and sociodemographic risk factors were identified and recorded during clinical assessment and were analyzed using nonparametric bivariate tests and multinomial regression for association with BUD, with <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05 for significance. Of the 150 AUD patients, 23 (15%) had comorbid BUD. Several variables were associated with ECAB score, with their independence being verified using multinomial regression, with lower risk of BUD versus BZD use, when the initial prescriber was an addiction specialist compared with a psychiatrist or a general practitioner [odds ratio (OR)\u2009=\u20090.12, 95% confidence interval (CI)\u2009=\u20090.14\u20130.75]. A higher risk of BZD use versus no use was evident when comorbid psychiatric disorders were present (OR\u2009=\u20099.2, 95%CI\u2009=\u20091.3\u201365). Our findings raise clinicians' awareness that in patients hospitalized for alcohol detoxification, BUD is highly prevalent but not specifically related to psychiatric disorders. BUD can be effectively screened by utilization of the ECAB.<\/jats:p>","DOI":"10.1111\/fcp.12888","type":"journal-article","created":{"date-parts":[[2023,3,7]],"date-time":"2023-03-07T01:19:43Z","timestamp":1678151983000},"page":"849-857","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prevalence of benzodiazepine use disorder during hospitalization for alcohol detoxification"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0239-5179","authenticated-orcid":false,"given":"Gilles","family":"Crosnier Leconte","sequence":"first","affiliation":[{"name":"Assistance Publique\u2010H\u00f4pitaux de Paris, GHU APHP. Nord DMU Neurosciences  Paris France"},{"name":"Universit\u00e9 de Paris Cit\u00e9, INSERM UMR\u2010S 1144  Paris France"},{"name":"FHU NOR\u2010SUD Network of Research in Substance Use Disorders  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2803-8249","authenticated-orcid":false,"given":"Virgile","family":"Clergue\u2010Duval","sequence":"additional","affiliation":[{"name":"Assistance Publique\u2010H\u00f4pitaux de Paris, GHU APHP. Nord DMU Neurosciences  Paris France"},{"name":"Universit\u00e9 de Paris Cit\u00e9, INSERM UMR\u2010S 1144  Paris France"},{"name":"FHU NOR\u2010SUD Network of Research in Substance Use Disorders  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanessa","family":"Bloch","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Paris Cit\u00e9, INSERM UMR\u2010S 1144  Paris France"},{"name":"FHU NOR\u2010SUD Network of Research in Substance Use Disorders  Paris France"},{"name":"Assistance Publique\u2010H\u00f4pitaux de Paris, GHU APHP. Nord, DMU Pharmacie Hospitali\u00e8re, DMU Biologie\u2010G\u00e9n\u00e9tique\u2010PUI  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Barre","sequence":"additional","affiliation":[{"name":"Assistance Publique\u2010H\u00f4pitaux de Paris, GHU APHP. 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Nord DMU Neurosciences  Paris France"},{"name":"Universit\u00e9 de Paris Cit\u00e9, INSERM UMR\u2010S 1144  Paris France"},{"name":"FHU NOR\u2010SUD Network of Research in Substance Use Disorders  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,3,15]]},"reference":[{"key":"e_1_2_16_2_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ps.201800321"},{"key":"e_1_2_16_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/phar.2170"},{"key":"e_1_2_16_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/003335491613100315"},{"key":"e_1_2_16_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228\u2010016\u20102044\u2010y"},{"key":"e_1_2_16_6_1","doi-asserted-by":"publisher","DOI":"10.3109\/10826084.2014.980952"},{"key":"e_1_2_16_7_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.18m12174"},{"key":"e_1_2_16_8_1","doi-asserted-by":"publisher","DOI":"10.1037\/1064\u20101297.2.3.244"},{"issue":"6","key":"e_1_2_16_9_1","first-page":"657","article-title":"Epidemiology of illicit substances use in France","volume":"70","author":"Milpied T","year":"2020","journal-title":"Rev Prat"},{"key":"e_1_2_16_10_1","first-page":"60","volume-title":"Etat des lieux de la consommation des benzodiazepines en France","author":"ANSM","year":"2017"},{"key":"e_1_2_16_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(10)61462\u20106"},{"key":"e_1_2_16_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2018.01.036"},{"key":"e_1_2_16_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/cns.12489"},{"key":"e_1_2_16_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.14165"},{"key":"e_1_2_16_15_1","doi-asserted-by":"publisher","DOI":"10.4088\/jcp.v65n0202"},{"key":"e_1_2_16_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2007.04.009"},{"key":"e_1_2_16_17_1","doi-asserted-by":"publisher","DOI":"10.3810\/pgm.2013.07.2684"},{"key":"e_1_2_16_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2008.07.017"},{"key":"e_1_2_16_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2017.01.013"},{"key":"e_1_2_16_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/14740338.2016.1221922"},{"key":"e_1_2_16_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102125.1981.tb01833.x"},{"key":"e_1_2_16_22_1","first-page":"510","article-title":"\u00c9valuation de la d\u00e9pendance aux benzodiaz\u00e9pines \u00e0 l'aide d'une \u00e9chelle cognitive","volume":"131","author":"P\u00e9lissolo A","year":"1993","journal-title":"Synapse"},{"volume-title":"Modalit\u00e9s d'arr\u00eat des benzodiaz\u00e9pines et m\u00e9dicaments apparent\u00e9s chez le patient \u00e2g\u00e9","year":"2008","author":"HAS","key":"e_1_2_16_23_1"},{"key":"e_1_2_16_24_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.169.3.276"},{"key":"e_1_2_16_25_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1360\u20100443.2000.95224511.x"},{"volume-title":"M\u00e9dicaments des troubles de l'usage d'alcool","year":"2021","author":"Sant\u00e9 Haute Autorit\u00e9","key":"e_1_2_16_26_1"},{"key":"e_1_2_16_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398\u2010021\u201001200\u20105"},{"key":"e_1_2_16_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.13547"},{"key":"e_1_2_16_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajad.12765"},{"key":"e_1_2_16_30_1","doi-asserted-by":"publisher","DOI":"10.2105\/ajph.83.9.1300"}],"container-title":["Fundamental &amp; 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