{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T22:19:46Z","timestamp":1780093186168,"version":"3.54.0"},"reference-count":46,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,3,17]],"date-time":"2023-03-17T00:00:00Z","timestamp":1679011200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Fundamemntal Clinical Pharma"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The treatment options are limited in <jats:italic>Acinetobacter\u2009baumannii<\/jats:italic> infections. In this study, the effectiveness of colistin monotherapy and combinations of colistin with different antibiotics were investigated in an experimental pneumonia model induced by carbapenem\u2010resistant <jats:styled-content style=\"fixed-case\"><jats:italic>A.\u00a0baumannii<\/jats:italic><\/jats:styled-content> strain. Mice in the study were divided into five groups as control (no treatment), colistin monotherapy, colistin\u2009+\u2009sulbactam, colistin\u2009+\u2009imipenem, and colistin\u2009+\u2009tigecycline combinations. The modified experimental surgical pneumonia model of Esposito and Pennington was applied to all groups. The presence of bacteria in blood and lung samples was investigated. Results were compared. In blood cultures, while there was no difference between the control and colistin groups, there was a statistical difference between the control and the combination groups (<jats:italic>P<\/jats:italic>\u2009=\u20090.029). When the groups were compared in terms of lung tissue culture positivity, there was a statistical difference between the control group and all treatment groups (colistin, colistin\u2009+\u2009sulbactam, colistin\u2009+\u2009imipenem, and colistin\u2009+\u2009tigecycline) (<jats:italic>P<\/jats:italic>\u2009=\u20090.026, <jats:italic>P<\/jats:italic>\u2009&lt; 0.001, <jats:italic>P<\/jats:italic>\u2009&lt; 0.001, and <jats:italic>P<\/jats:italic>\u2009=\u20090.002, respectively). The number of microorganisms that grew in the lung tissue was found to be statistically significantly lower in all treatment groups in comparison with the control group (<jats:italic>P<\/jats:italic>\u2009=\u20090.001). Both monotherapy and combination therapies of colistin were found to be effective in the treatment of carbapenem\u2010resistant <jats:italic>A.\u00a0baumannii<\/jats:italic> pneumonia, but the superiority of combination therapies over colistin monotherapy has not been demonstrated.<\/jats:p>","DOI":"10.1111\/fcp.12891","type":"journal-article","created":{"date-parts":[[2023,3,11]],"date-time":"2023-03-11T06:14:53Z","timestamp":1678515293000},"page":"816-823","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Evaluation of combination therapies with colistin in an experimental mouse pneumonia model induced by carbapenem\u2010resistant <i>Acinetobacter\u2009baumannii<\/i> strain"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0409-4476","authenticated-orcid":false,"given":"Onur","family":"Unal","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Department of Infectious Diseases and Clinical Microbiology Suleyman Demirel University  Isparta Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Onur","family":"Kaya","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Infectious Diseases and Clinical Microbiology Suleyman Demirel University  Isparta Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuba","family":"Ozturk","sequence":"additional","affiliation":[{"name":"Laboratory of Medical Microbiology Isparta City Hospital  Isparta Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emel Sesli","family":"Cetin","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Medical Microbiology Suleyman Demirel University  Isparta Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibak","family":"Gonen","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology Istanbul Aydin University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esra Nurlu","family":"Temel","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Infectious Diseases and Clinical Microbiology Suleyman Demirel University  Isparta Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8691-035X","authenticated-orcid":false,"given":"Fusun Zeynep","family":"Akcam","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Infectious Diseases and Clinical Microbiology Suleyman Demirel University  Isparta Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,3,17]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkh485"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13756\u2010019\u20100502\u2010x"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkp428"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1017\/S095026881200194X"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1086\/653120"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics11030421"},{"key":"e_1_2_11_8_1","doi-asserted-by":"crossref","DOI":"10.1093\/cid\/ciab1013","volume-title":"Infectious Diseases Society of America Guidance on the Treatment of Ampc \u03b2\u2010Lactamase\u2014Producing Enterobacterales, Carbapenem\u2010Resistant Acinetobacter\u2009baumannii, and Stenotrophomonas\u2009maltophilia Infections","author":"Tamma P","year":"2022"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/22221751.2019.1698273"},{"key":"e_1_2_11_10_1","volume-title":"Antibiotic Resistance Threats in the United States, 2019","author":"CDC","year":"2019"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgar.2020.08.021"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469\u20100691.2004.00987.x"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkm136"},{"key":"e_1_2_11_14_1","first-page":"2723","volume-title":"Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases","author":"Hochman S","year":"2019"},{"key":"e_1_2_11_15_1","unstructured":"Clinical and Laboratory Standards Institute (CLSI). 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