{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:09:04Z","timestamp":1747184944159,"version":"3.40.5"},"reference-count":15,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,5,16]],"date-time":"2023-05-16T00:00:00Z","timestamp":1684195200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Fundamemntal Clinical Pharma"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>There is a paucity of clinical data about whether sugammadex forms precipitates with other medications. This laboratory experimental study was performed to determine the drugs that produce precipitates with sugammadex. Samples of 1\u00a0ml of sugammadex were prepared in transparent cylinders, to which 1\u00a0ml of test drugs (rocuronium, neostigmine, glycopyrrolate, atropine, nitroglycerin, dobutamine, dopamine, epinephrine, vasopressin, norepinephrine, phenylephrine, ephedrine, esmolol, nicardipine, and labetalol) was added. The precipitation reaction was observed visually and via light microscope. The pH of each drugs before and after mixing with sugammadex was measured. White crystals were formed when sugammadex was mixed with nicardipine or labetalol. Sugammadex formed precipitate when mixed with nicardipine or labetalol. Sufficient fluid flushing is required between injections of each drug to prevent these reactions.<\/jats:p>","DOI":"10.1111\/fcp.12913","type":"journal-article","created":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T10:43:15Z","timestamp":1682937795000},"page":"1006-1010","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Precipitation of sugammadex with nicardipine and labetalol: A laboratory research"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7828-618X","authenticated-orcid":false,"given":"Jiwon","family":"Han","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine Chung\u2010Ang University College of Medicine  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3659-6171","authenticated-orcid":false,"given":"Ah\u2010Young","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine Seoul National University Bundang Hospital  Seongnam Republic of Korea"},{"name":"Department of Anesthesiology and Pain Medicine Seoul National University College of Medicine  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,5,16]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.5535\/arm.2016.40.1.21"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03018114"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1258\/shorts.2011.011031"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD012763"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0034\u20107094(13)70208\u20103"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinane.2011.04.004"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinane.2019.109680"},{"volume-title":"Inorganic chemistry","year":"2012","author":"Housecroft CE","key":"e_1_2_14_9_1"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1358\/dof.2003.028.04.742715"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.4103\/0259\u20101162.123211"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm011107f"},{"issue":"2","key":"e_1_2_14_13_1","first-page":"266","article-title":"A novel concept of reversing neuromuscular block: chemical encapsulation of rocuronium bromide by a cyclodextrin\u2010based synthetic host","volume":"41","author":"Bom A","year":"2002","journal-title":"Angew Chem Int Ed Engl"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03256937"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03012027"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.26.7.1247"}],"container-title":["Fundamental &amp; Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/fcp.12913","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T12:36:24Z","timestamp":1694176584000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/fcp.12913"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,16]]},"references-count":15,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["10.1111\/fcp.12913"],"URL":"https:\/\/doi.org\/10.1111\/fcp.12913","archive":["Portico"],"relation":{},"ISSN":["0767-3981","1472-8206"],"issn-type":[{"type":"print","value":"0767-3981"},{"type":"electronic","value":"1472-8206"}],"subject":[],"published":{"date-parts":[[2023,5,16]]},"assertion":[{"value":"2023-02-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}