{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T10:43:29Z","timestamp":1766486609898,"version":"3.40.5"},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,6,3]],"date-time":"2023-06-03T00:00:00Z","timestamp":1685750400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002261","name":"Russian Foundation for Basic Research","doi-asserted-by":"publisher","award":["18\u2010015\u201000008","18\u2010015\u201000009"],"award-info":[{"award-number":["18\u2010015\u201000008","18\u2010015\u201000009"]}],"id":[{"id":"10.13039\/501100002261","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Fundamemntal Clinical Pharma"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Objectives:<\/jats:bold>The aim of this work was to elucidate the role of GalR2 receptor activation in protecting the rat heart in vivo from ischemia\/reperfusion (I\/R) damage by a pharmacological peptide agonist WTLNSAGYLLGP\u03b2AH\u2010OH (G1) and full\u2010length rat galanin GWTLNSAGYLLGPHAIDNHRSFSDKHGLT\u2010NH2 (G2) using M871, a selective inhibitor of GalR2.<jats:bold>Methods:<\/jats:bold>The peptides were prepared by the automatic solid\u2010phase synthesis using the Fmoc\u2010strategy and purified by high\u2010performance liquid chromatography (HPLC). A 40\u2010min left anterior descending (LAD) coronary artery occlusion followed by a 60\u2010min reperfusion was performed. The criteria for damage\/protection of the heart were the infarct size (IS) and plasma activity of creatine kinase\u2010MB (CK\u2010MB) at the end of reperfusion.<jats:bold>Results:<\/jats:bold>Intravenous injection of G1 or G2 at an optimal dose of 1\u00a0mg\/kg at the fifth minute of reperfusion significantly reduced the IS (by 35% and 32%, respectively) and activity of CK\u2010MB at the end of reperfusion (by 43% and 38%, respectively) compared with the control. Administration of M871 (8\u00a0mg\/kg) 5\u00a0min before the onset of reperfusion abolished the effects of G1 on IS and CK\u2010MB activity, returning them to control values. Co\u2010administration of M871 (8\u00a0mg\/kg) with G2 attenuated protective effect of G2 on both IS and plasma \u0421K\u2010MB activity. However, differences in these parameters between the M871+G2 and G2 groups did not reach statistical significance (<jats:italic>P<\/jats:italic>\u2009=\u20090.139 and<jats:italic>P<\/jats:italic>\u2009=\u20090.121, respectively).<jats:bold>Conclusion:<\/jats:bold>Thus, GalR2 is the principal receptor subtype that transduces the protective effects of galanin and ligand G1 in myocardial I\/R injury. This suggests that GalR2\u2010specific peptide agonists could be used as drug candidates for treating ischemic heart disease.<\/jats:p>","DOI":"10.1111\/fcp.12925","type":"journal-article","created":{"date-parts":[[2023,5,30]],"date-time":"2023-05-30T09:11:45Z","timestamp":1685437905000},"page":"1109-1118","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Exogenous GalR2\u2010specific peptide agonist as a tool for treating myocardial ischemia\/reperfusion injury"],"prefix":"10.1111","volume":"37","author":[{"given":"Larisa","family":"Serebryakova","sequence":"first","affiliation":[{"name":"Chazov National Medical Research Center of Cardiology Moscow Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oksana","family":"Veselova","sequence":"additional","affiliation":[{"name":"Chazov National Medical Research Center of Cardiology Moscow 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