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Since pre\u2010eclampsia is a growing public health threat, it may negatively impact the economy and increase the disease burden of South Africa. Phytocompounds are easily accessible, demonstrate minimal side effects, and may confer novel medicinal options as a treatment and preventive preference.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the physiological, biochemical, and hematological outcomes of hesperidin in an arginine vasopressin (AVP)\u2010induced rodent model of pre\u2010eclampsia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Female Sprague\u2013Dawley rats were surgically implanted with mini\u2010osmotic pumps to deliver AVP (200\u2009ng\/h) subcutaneously. Animals were treated with hesperidin at 200\u2009mg\/kg.b.w via oral gavage for 14\u2009days. Systolic and diastolic blood pressures were measured on GD 7, 14, and 18 using a non\u2010invasive tail\u2010cuff method and were euthanized on GD 21.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The findings showed that hesperidin administration significantly decreased blood pressure (<jats:italic>P\u2009&lt;\u20090.05<\/jats:italic>) and urinary protein levels in pregnant rats (<jats:italic>P\u2009&lt;\u20090.001<\/jats:italic>). Placental and individual pup weight also increased significantly in the pregnant hesperidin\u2010treated groups compared to AVP untreated groups (<jats:italic>P\u2009&lt;\u20090.001<\/jats:italic>). Biochemical and hematological markers such as white blood cell count and lymphocyte levels differed significantly (<jats:italic>P\u2009&lt;\u20090.05<\/jats:italic>) in AVP groups treated with and without hesperidin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results suggest that hesperidin is an antihypertensive agent with modes of action associated with its diuretic and blood pressure lowering effects and reduction of proteinuria in AVP\u2010induced pre\u2010eclamptic rats.<\/jats:p><\/jats:sec>","DOI":"10.1111\/fcp.12952","type":"journal-article","created":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:39:10Z","timestamp":1693528750000},"page":"341-350","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Hesperidin improves physiological outcomes in an arginine vasopressin rat model of pre\u2010eclampsia"],"prefix":"10.1111","volume":"38","author":[{"given":"Rebecca","family":"Reddy","sequence":"first","affiliation":[{"name":"Department of Basic Medical Sciences, Faculty of Health Sciences Durban University of Technology  Durban South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sooraj","family":"Baijnath","sequence":"additional","affiliation":[{"name":"Integrated Molecular Physiology Research Initiative, School of Physiology, Faculty of Health Sciences University of the Witwatersrand  Johannesburg South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanil","family":"Singh","sequence":"additional","affiliation":[{"name":"Biomedical Resource Unit University of KwaZulu\u2010Natal  Durban South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roshila","family":"Moodley","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Manchester  Manchester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thajasvarie","family":"Naicker","sequence":"additional","affiliation":[{"name":"Discipline of Optics and Imaging, Doris Duke Medical Research Institute, College of Health Sciences University of KwaZulu\u2010Natal  Durban South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4047-6340","authenticated-orcid":false,"given":"Nalini","family":"Govender","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Sciences, Faculty of Health Sciences Durban University of Technology  Durban South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,8,31]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/alcalc\/agt007"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.113.073106"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753\u20104887.2012.00508.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00011\u2010010\u20100295\u20100"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.2856"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.110.004945"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.1074"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031\u20109422(88)80625\u20103"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfca.2013.11.004"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27041320"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ypmed.2012.02.012"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.5670"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.3177\/jnsv.48.420"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2017.09.010"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.3177\/jnsv.54.95"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1039\/c3fo60030k"},{"issue":"3","key":"e_1_2_9_18_1","first-page":"219","article-title":"Biological effects of hesperidin, a citrus flavonoid. 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