{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T06:02:34Z","timestamp":1777442554213,"version":"3.51.4"},"reference-count":51,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T00:00:00Z","timestamp":1700697600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006191","name":"Eski\u015fehir Osmangazi \u00dcniversitesi","doi-asserted-by":"publisher","award":["2017\u201011004"],"award-info":[{"award-number":["2017\u201011004"]}],"id":[{"id":"10.13039\/501100006191","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Fundamemntal Clinical Pharma"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Chemotherapy\u2010induced peripheral neuropathy (CIPN) is still an unresolved problem in cisplatin (CIS) use.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This study investigates possible anti\u2010neuropathic effect of chlorogenic acid (CGA) against CIS\u2010induced CIPN in rats while also investigating the contribution of nitric oxide (NO) to this phenomenon.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Initially, CGA (250\u20131000\u2009\u03bcM) was tested by MTT assay on primary DRG neurons. Subsequently, CIPN was induced in Sprague\u2013Dawley rats by 3\u2009mg\/kg intraperitoneal injections of CIS once\/week for 5\u00a0weeks. CGA (100\u2009mg\/kg) was co\u2010administered with CIS, both alone and in combination with <jats:sc>l<\/jats:sc>\u2010arginine (LARG) or <jats:sc>l<\/jats:sc>\u2010nitro\u2010arginine\u2010methyl\u2010ester (LNAME), to elucidate the contribution of nitrergic system to anti\u2010neuropathic effects. Mechanical allodynia, thermal hyperalgesia, and cold plate tests were performed to test CIPN. Rotarod, footprint analysis, and activitymeter were used to evaluate motor coordination and performance. Tumor necrosis factor alpha (TNF\u2010\u03b1) was measured as a marker of inflammation. Histological evaluations of DRG and sciatic nerves (SNs) were performed utilizing toluidine blue staining. Two\u2010way analysis of variance and Kruskal\u2013Wallis following Tukey's test were used as statistical analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Higher concentration of CGA (1000\u2009\u03bcM) exhibited protective effect against in vitro neurotoxicity. Neither LARG nor LNAME exerted significant change in this effect. Co\u2010administration of CGA alleviated histological abnormalities and neuropathic effects induced by CIS. Ameliorative effect of CGA was not changed in mechanical allodynia but attenuated in cold allodynia, and motor activity\/coordination tests by LARG and LNAME. Neuropathic effects of CIS remained unchanged with LARG and LNAME in behavioral experiments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The study identified CGA as candidate agent in mitigating CIPN. NO seems to play a modulatory role in this effect.<\/jats:p><\/jats:sec>","DOI":"10.1111\/fcp.12970","type":"journal-article","created":{"date-parts":[[2023,11,25]],"date-time":"2023-11-25T00:49:44Z","timestamp":1700873384000},"page":"523-537","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Chlorogenic acid co\u2010administration alleviates cisplatin\u2010induced peripheral neuropathy in rats"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7680-0141","authenticated-orcid":false,"given":"\u00c7i\u011fdem \u00c7engelli","family":"\u00dcnel","sequence":"first","affiliation":[{"name":"Faculty of Medicine Department of Medical Pharmacology Eskisehir Osmangazi University  Eskisehir 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