{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:07:02Z","timestamp":1747184822384,"version":"3.40.5"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,11,27]],"date-time":"2023-11-27T00:00:00Z","timestamp":1701043200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100013607","name":"American College of Clinical Pharmacy","doi-asserted-by":"publisher","award":["RI Futures Grant"],"award-info":[{"award-number":["RI Futures Grant"]}],"id":[{"id":"10.13039\/100013607","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005496","name":"American Foundation for Pharmaceutical Education","doi-asserted-by":"publisher","award":["Gateway to Research Scholarship"],"award-info":[{"award-number":["Gateway to Research Scholarship"]}],"id":[{"id":"10.13039\/100005496","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Fundamemntal Clinical Pharma"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Vitamin D deficiency is a common finding in critically ill children. However, the optimal supplementation strategy in this patient population is unknown. The objective of this study was to evaluate the effects of high\u2010dose (10\u2009000\u2009IU\/kg, max. 400\u2009000\u00a0IU) vitamin D supplementation on 25\u2010hydroxyvitamin D3 (25[OH]D3) levels in pediatric intensive care unit (PICU) patients with baseline vitamin D deficiency.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a prospective, institutional review board\u2010approved pilot research study performed at the University of South Alabama Women's and Children's Hospital in Mobile, AL. The study sample consisted of patients less than 18\u2009years old admitted to the PICU with baseline 25\u2010hydroxyvitamin D (25[OH]D) level less than 30\u2009ng\/ml. Included patients received a one\u2010time dose of vitamin D3 orally or via gastric tube (10\u2009000\u2009IU\/kg, max. 400\u2009000\u00a0IU).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 17 patients were screened with 11 included in the study. Blood analysis revealed a significant increase in 25(OH)D3 level from baseline to 12\u2010h post dose (21.6 [4.5] ng\/ml vs. 46.7 [15.5] ng\/ml, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). At the 12\u2010h post\u2010dose time point, 10\/11 patients (91%) had 25(OH)D3 levels that were greater than 30\u2009ng\/ml. No adverse effects were observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Vitamin D3 supplementation at a dose of 10\u2009000\u2009IU\/kg (max. 400\u2009000\u00a0IU) significantly increased 25(OH)D3 levels in critically ill pediatric patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/fcp.12973","type":"journal-article","created":{"date-parts":[[2023,11,28]],"date-time":"2023-11-28T00:39:42Z","timestamp":1701131982000},"page":"588-595","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prospective pilot study evaluating a vitamin D3 loading dose in critically ill children with vitamin D deficiency"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0082-6008","authenticated-orcid":false,"given":"Elizabeth W.","family":"Covington","sequence":"first","affiliation":[{"name":"Harrison College of Pharmacy Auburn University  Auburn Alabama 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