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This systematic review aims to summarize and evaluate the antimalarial activities of benzothiazole analogs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted an electronic search using nine databases in October 2017 and subsequently updated in September 2022. We included all original in vitro and in vivo studies that documented the antimalarial activities of compounds containing benzothiazole analogs with no restriction. The risk of bias of each included study was assessed by ToxRTool.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010eight articles were included in our study, which are in vitro, in vivo, or both. Of these, 232 substances were identified to have potent antiplasmodial activity against various strains of the malaria parasite. Benzothiazole analogs show different antimalarial mechanisms, including inhibition of <jats:italic>Plasmodium falciparum<\/jats:italic> enzymes in in vitro studies and inhibition of blood parasites in in vivo studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Benzothiazole derivatives are promising substances for treating malaria. The structure\u2013activity relationship studies suggest that the substitution pattern of the benzothiazole scaffold plays a crucial role in determining the antimalarial activity of the analog.<\/jats:p><\/jats:sec>","DOI":"10.1111\/fcp.12974","type":"journal-article","created":{"date-parts":[[2023,12,26]],"date-time":"2023-12-26T11:16:00Z","timestamp":1703589360000},"page":"410-464","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Antimalarial activities of benzothiazole analogs: A systematic review"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8667-082X","authenticated-orcid":false,"given":"Linh","family":"Tran","sequence":"first","affiliation":[{"name":"Institute of Fundamental and Applied Sciences Duy Tan University  Ho Chi Minh City Vietnam"},{"name":"Faculty of Natural Sciences Duy Tan University  Da Nang 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