{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T12:41:51Z","timestamp":1791636111770,"version":"4.3.4"},"reference-count":120,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,2,29]],"date-time":"2024-02-29T00:00:00Z","timestamp":1709164800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012190","name":"Ministry of Science and Higher Education of the Russian Federation","doi-asserted-by":"publisher","award":["122020300042\u20104"],"award-info":[{"award-number":["122020300042\u20104"]}],"id":[{"id":"10.13039\/501100012190","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Fundamemntal Clinical Pharma"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Catecholamines and \u03b2\u2010adrenergic receptors (\u03b2\u2010ARs) play an important role in the regulation of cardiac tolerance to the impact of ischemia and reperfusion. This systematic review analyzed the molecular mechanisms of the cardioprotective activity of \u03b2\u2010AR ligands.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed an electronic search of topical articles using PubMed databases from 1966 to 2023. We cited original in vitro and in vivo studies and review articles that documented the cardioprotective properties of \u03b2\u2010AR agonists and antagonists.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The infarct\u2010reducing effect of \u03b2\u2010AR antagonists did not depend on a decrease in the heart rate. The target for \u03b2\u2010blockers is not only cardiomyocytes but also neutrophils. \u03b21\u2010blockers (metoprolol, propranolol, timolol) and the selective \u03b22\u2010AR agonist arformoterol have an infarct\u2010reducing effect in coronary artery occlusion (CAO) in animals. Antagonists of \u03b21\u2010 and \u03b22\u2010\u0410R (metoprolol, propranolol, nadolol, carvedilol, bisoprolol, esmolol) are able to prevent reperfusion cardiac injury. All \u03b2\u2010AR ligands that reduced infarct size are the selective or nonselective \u03b21\u2010blockers. It was hypothesized that \u03b21\u2010AR blocking promotes an increase in cardiac tolerance to I\/R. The activation of \u03b21\u2010AR, \u03b22\u2010AR, and \u03b23\u2010AR can increase cardiac tolerance to I\/R. The cardioprotective effect of \u03b2\u2010AR agonists is mediated via the activation of kinases and reactive oxygen species production.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>It is unclear why \u03b2\u2010blockers with the similar receptor selectivity have the infarct\u2010sparing effect while other \u03b2\u2010blockers with the same selectivity do not affect infarct size. What is the molecular mechanism of the infarct\u2010reducing effect of \u03b2\u2010blockers in reperfusion? Why did in early studies \u03b2\u2010blockers decrease the mortality rate in patients with acute myocardial infarction (AMI) and without reperfusion and in more recent studies \u03b2\u2010blockers had no effect on the mortality rate in patients with AMI and reperfusion? The creation of more effective \u03b2\u2010AR ligands depends on the answers to these questions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/fcp.12988","type":"journal-article","created":{"date-parts":[[2024,2,29]],"date-time":"2024-02-29T21:38:13Z","timestamp":1709242693000},"page":"658-673","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["The role of \u03b2\u2010adrenergic receptors in the regulation of cardiac tolerance to ischemia\/reperfusion. Why do \u03b2\u2010adrenergic receptor agonists and antagonists protect the heart?"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6020-1598","authenticated-orcid":false,"given":"Leonid N.","family":"Maslov","sequence":"first","affiliation":[{"name":"Cardiology Research Institute, Tomsk National Research Medical Centre Russian Academy of Sciences  Tomsk Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2264-1928","authenticated-orcid":false,"given":"Natalia V.","family":"Naryzhnaya","sequence":"additional","affiliation":[{"name":"Cardiology Research Institute, Tomsk National Research Medical Centre Russian Academy of Sciences  Tomsk Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikita S.","family":"Voronkov","sequence":"additional","affiliation":[{"name":"Cardiology Research Institute, Tomsk National Research Medical Centre Russian Academy of Sciences  Tomsk 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