{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T19:06:51Z","timestamp":1776625611763,"version":"3.51.2"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,2,11]],"date-time":"2024-02-11T00:00:00Z","timestamp":1707609600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Fundamemntal Clinical Pharma"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>While ursodeoxycholic acid is used in treating parenteral nutrition\u2010associated cholestasis (PNAC) in neonates, its role in prevention is unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>In this systematic review and meta\u2010analysis, we attempted to determine the role of ursodeoxycholic acid in preventing PNAC in neonates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>PubMed, Embase, Cochrane Library, Scopus, and CINAHL databases were searched on September 16, 2023, for interventional studies comparing ursodeoxycholic acid with placebo.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 6180 unique records identified, five studies were eligible for inclusion (three randomised and two nonrandomised). Evidence from randomised trials showed that ursodeoxycholic acid prophylaxis did not reduce cholestasis, mortality, sepsis, and necrotising enterocolitis. Ursodeoxycholic acid prophylaxis reduced feed intolerance (RR 0.23 (0.09, 0.64); 1 RCT, 102 neonates), peak conjugated bilirubin levels (MD \u22120.13 (\u22120.22, \u22120.04) mg\/dL; 1 RCT, 102 neonates), and time to full enteral feeds (MD \u22122.7 (\u22125.09, \u22120.31) days; 2 RCTs, 76 neonates). There was no decrease in hospital stay and parenteral nutrition duration. Data from nonrandomised studies did not show benefit in any of the outcomes. The certainty of the evidence was low to very low.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Because of the very low\u2010quality evidence and lack of evidence on critical outcomes, definitive conclusions could not be made on using ursodeoxycholic acid to prevent parenteral nutrition\u2010associated cholestasis in neonates.<\/jats:p><\/jats:sec>","DOI":"10.1111\/fcp.12993","type":"journal-article","created":{"date-parts":[[2024,2,12]],"date-time":"2024-02-12T01:24:15Z","timestamp":1707701055000},"page":"685-694","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Ursodeoxycholic acid for preventing parenteral nutrition\u2010associated cholestasis in neonates: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1572-4453","authenticated-orcid":false,"given":"Rajendra Prasad","family":"Anne","sequence":"first","affiliation":[{"name":"Neonatology, Kasturba Medical College Manipal Academy of Higher Education (MAHE)  Manipal India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Srikanth Puttaiah","family":"Kadyada","sequence":"additional","affiliation":[{"name":"Manipal Hospitals  Bangalore India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abhishek Somasekhara","family":"Aradhya","sequence":"additional","affiliation":[{"name":"Ovum Hospitals  Hoskote India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tejo Pratap","family":"Oleti","sequence":"additional","affiliation":[{"name":"Fernandez Hospitals  Hyderabad India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,2,11]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.13195"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2022.02.002"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild\u20102021\u2010321643"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.112.042028"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14050919"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD013141.pub2"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2014.02.006"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jpen.1843"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1542\/neo.22\u201012\u2010e819"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607113496280"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/163632"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2012.03.062"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607109332772"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2004\u20101014"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607186010003282"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20110184"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0280691"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e3181560524"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2011.56"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.2298\/sarh1404184s"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2002.125802"},{"key":"e_1_2_10_23_1","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions Version 6.4 (Updated August 2023)","author":"Higgins J","year":"2023"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwm189"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2010.04.027"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l4898"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i4919"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39489.470347.AD"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12519\u2010021\u201000487\u20100"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1159\/000514763"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13052\u2010015\u20100178\u20107"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.21037\/pm.2018.10.01"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.4103\/1319\u20103767.141688"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12887\u2010023\u201004068\u20100"},{"key":"e_1_2_10_36_1","volume-title":"Sample Size Calculator for Comparing Two Independent Proportions","author":"Singh ND"}],"container-title":["Fundamental &amp; Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/fcp.12993","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,17]],"date-time":"2024-07-17T09:25:09Z","timestamp":1721208309000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/fcp.12993"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,11]]},"references-count":35,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["10.1111\/fcp.12993"],"URL":"https:\/\/doi.org\/10.1111\/fcp.12993","archive":["Portico"],"relation":{},"ISSN":["0767-3981","1472-8206"],"issn-type":[{"value":"0767-3981","type":"print"},{"value":"1472-8206","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,11]]},"assertion":[{"value":"2023-12-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}