{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:40:48Z","timestamp":1791308448619,"version":"4.3.1"},"reference-count":38,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,3,12]],"date-time":"2024-03-12T00:00:00Z","timestamp":1710201600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Fundamemntal Clinical Pharma"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Adenosinergic system has been implicated in the pathophysiology of bipolar disorder and drugs that affect adenosine neurotransmission have shown some efficacy as add\u2010on therapy in manic patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>Thus, the aim of the present study was to screen adenosinergic drugs for antimanic\u2010like effect in methylphenidate (MPH)\u2010induced hyperlocomotion in mice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Male and female Swiss mice received a single allopurinol (50 and 200\u2009mg\/kg, ip), dipyridamole (20\u2009mg\/kg, ip), or inosine (50\u2009mg\/kg, ip) administration before an acute MPH challenge (5\u00a0mg\/kg, sc). In experiments with repeated treatment, male mice received a daily administration of allopurinol (25 and 50\u2009mg\/kg, ip), dipyridamole (20\u2009mg\/kg, ip), or inosine (50\u2009mg\/kg, ip) for 14\u2009days. Finally, pretreatment with aminophylline (2\u00a0mg\/kg, sc), an unspecific adenosine receptor antagonist, was used to evaluate a putative adenosinergic mediation. Locomotor activity was measured in the automated activity chamber for 20\u2009min.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Acute and repeated dipyridamole reduced the increase in locomotor activity induced by MPH, while allopurinol and inosine had no effect. Aminophylline blocked the effect of dipyridamole in MPH\u2010induced hyperlocomotion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The present results suggest that dipyridamole may have an antimanic\u2010like effect through adenosine receptors and reinforce the proposal that the adenosine system may be an interesting target for new antimanic drugs.<\/jats:p><\/jats:sec>","DOI":"10.1111\/fcp.13001","type":"journal-article","created":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T03:10:37Z","timestamp":1710299437000},"page":"897-905","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Antimanic\u2010like effect of dipyridamole in the methylphenidate\u2010induced hyperlocomotion"],"prefix":"10.1111","volume":"38","author":[{"given":"Anderson Gustavo","family":"Santos","sequence":"first","affiliation":[{"name":"Laboratory of Physiology and Pharmacology of the Central Nervous System, 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