{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:07:10Z","timestamp":1747184830157,"version":"3.40.5"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,8,13]],"date-time":"2024-08-13T00:00:00Z","timestamp":1723507200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004484","name":"Tehran University of Medical Sciences and Health Services","doi-asserted-by":"publisher","award":["1401\u20102\u2010101\u201058628"],"award-info":[{"award-number":["1401\u20102\u2010101\u201058628"]}],"id":[{"id":"10.13039\/501100004484","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Fundamemntal Clinical Pharma"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Renal ischemia reperfusion injury (IRI) is a post\u2010ischemic event, which can lead to subsequent acute kidney injury (AKI), transplant failure, renal dysfunction and fibrosis via heightened oxidative stress and production of inflammatory cytokines and chemokines.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aims to assess the effect of Modafinil, a wake\u2010promoting agent with previously proven anti\u2010inflammatory and anti\u2010oxidative properties, on ameliorating renal IRI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 30 male Wistar rats were divided into five groups: Sham\u2010operated group, ischemia reperfusion (I\/R) control group and Modafinil pre\u2010treated groups (at different doses of 50, 100 and 150\u2009mg\/kg). IRI was induced by means of bilaterally clamping the renal arteries for 45\u2009min, followed by 24\u2009h of reperfusion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Tissue pathological assessments demonstrated a reduction of glomerular, vascular and interstitial injury at doses of 50 and 100\u2009mg\/kg of Modafinil. The biochemical studies showed a significant decrease in tissue pro\u2010inflammatory factors, including tumor necrosis factor alpha (TNF\u2010\u03b1), Interleukin\u201018 (IL\u201018) and lactate dehydrogenase (LDH). Moreover, an elevation was observed in levels of super oxide dismutase (SOD) and catalase, indicating the reduction of oxidative stress. Furthermore, the levels of creatinine (Cr), urea and neutrophil gelatinase\u2010associated lipocalin (NGAL) were declined, indicating the improvement in renal function at effective doses of Modafinil (50 and 100\u2009mg\/kg) compared to the I\/R control group without Modafinil pre\u2010treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings suggest that Modafinil holds promise as an effective therapeutic agent to address the clinical challenges associated with kidney IRI reducing the need for hospitalization and potentially alleviating related morbidities.<\/jats:p><\/jats:sec>","DOI":"10.1111\/fcp.13034","type":"journal-article","created":{"date-parts":[[2024,8,14]],"date-time":"2024-08-14T03:04:56Z","timestamp":1723604696000},"page":"1168-1177","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Exploring the therapeutic potential of Modafinil in mitigating renal 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