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The inflammatory process involved in this pathology is a defense mechanism of the body against infectious agents and\/or tissue injuries. However, when the condition is not reversed, it becomes a significant cause of tissue damage, sometimes leading to loss of function of the affected organ. Therefore, it is essential to understand the mechanisms underlying inflammation, as well as the development of new therapeutic agents that reduce inflammatory damage in these cases. Aryl\u2010cyclohexanone derivatives have previously shown significant anti\u2010inflammatory activity linked to an immunomodulatory capacity in vitro and may be good candidates for therapies in which inflammation plays a central role.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Was evaluated the anti\u2010inflammatory capacity of a synthesized molecule aryl\u2010cyclohexanone in the murine model of lipopolysaccharide (LPS)\u2010induced acute lung injury. The assessment of acute oral toxicity follows the Organization for Economic Co\u2010operation and Development (OECD) guideline 423.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The results demonstrated that the studied molecule protects against LPS\u2010induced inflammation. We observed a decrease in the migration of total and differential leukocytes to the bronchoalveolar lavage fluid (BALF), in addition to a reduction in exudation, myeloperoxidase (MPO) activity, nitric oxide metabolites, and the secretion of pro\u2010inflammatory cytokines (alpha tumor necrosis factors [TNF\u2010\u03b1], interleukin\u20106 [IL\u20106], interferon\u2010gamma [IFN\u2010\u03b3], and monocyte chemoattractant protein\u20101 [MCP\u20101]). Finally, aryl cyclohexanone did not show signs of acute oral toxicity (OECD 423).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The results prove our hypothesis that aryl\u2010cyclohexanone is a promising molecule for developing a new, safe anti\u2010inflammatory drug.<\/jats:p><\/jats:sec>","DOI":"10.1111\/fcp.13035","type":"journal-article","created":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T01:09:29Z","timestamp":1724029769000},"page":"1103-1115","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Preclinical evidence of the anti\u2010inflammatory effect and toxicological safety of aryl\u2010cyclohexanone in vivo"],"prefix":"10.1111","volume":"38","author":[{"given":"Tain\u00e1 Larissa","family":"Lubschinski","sequence":"first","affiliation":[{"name":"Department of Clinical Analysis, Center of Health Sciences Federal University of Santa Catarina  Florian\u00f3polis 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