{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T14:16:48Z","timestamp":1773929808675,"version":"3.50.1"},"reference-count":82,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,11,4]],"date-time":"2024-11-04T00:00:00Z","timestamp":1730678400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,11,4]],"date-time":"2024-11-04T00:00:00Z","timestamp":1730678400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Fundamemntal Clinical Pharma"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Fibromyalgia (FM) is a syndrome of pervasive chronic pain accompanied by low mood, sleep disorders, and cognitive decline. The dysfunction of central pain processing systems along with neurotransmitter disturbances are possible contributing mechanisms. Genetic polymorphism of the \ud835\udefd2 adrenergic receptors is reported in FM patients. It is reported that chronic \u03b22 agonists administration is effective for neuropathic pain alleviation. No current information, however, exists on their potential to alleviate nociplastic pain, such as FM. Therefore, the purpose of the current study is to examine salmeterol's potential antiallodynic effects in experimentally produced FM and explore some of the possible contributing mechanisms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Thirty rats are allocated into three groups (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200910): a normal group, a reserpine group that received reserpine (1\u2009mg\/kg; s.c.) for 3\u2009days, and a reserpine + salmeterol group that received salmeterol (1\u2009mg\/kg; i.p.) for 21 consecutive days following last reserpine injection.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Reserpine administration resulted in behavioral and biochemical changes consistent with FM, including thermal and mechanical hyperalgesia, depressive behavior, and motor incoordination. This is coupled with disturbed spinal monoamine levels, depressed cyclic adenosine monophosphate (cAMP)\/protein kinase A (PKA) signaling, disturbed mitochondrial function\/dynamics, and compromised blood\u2010nerve barrier integrity. Treatment with salmeterol conceivably reversed these effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\u03b22 receptor agonists such as salmeterol could be regarded as a promising strategy for the management of FM.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/fcp.13041","type":"journal-article","created":{"date-parts":[[2024,11,4]],"date-time":"2024-11-04T20:20:23Z","timestamp":1730751623000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["New ways to repurpose salmeterol in an animal model of fibromyalgia"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-3071-0758","authenticated-orcid":false,"given":"Mena Z.","family":"Shafiek","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Toxicology, Faculty of Dentistry Misr International University  Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hala F.","family":"Zaki","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Faculty of Pharmacy Cairo University  Cairo 11562 Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed F.","family":"Mohamed","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Faculty of Pharmacy Cairo University  Cairo 11562 Egypt"},{"name":"Faculty of Pharmacy King Salman International University (KSIU)  South Sinai 46612 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