{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T14:16:48Z","timestamp":1773929808931,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T00:00:00Z","timestamp":1731024000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T00:00:00Z","timestamp":1731024000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100020210","name":"Olav Raagholt og Gerd Meidel Raagholts stiftelse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020210","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Fundamemntal Clinical Pharma"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>DNA repair plays a major role in maintaining genomic stability, thus limiting the transformation of normal cells into cancer cells. However, in cancer patients treated with DNA\u2010targeting drugs, DNA repair can decrease efficacy by removing the damage generated by such molecules that is needed to induce pharmacological activity. Inhibiting DNA repair thus represents an interesting approach to potentiating the activity of chemotherapy in this setting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      Here, we continue the characterization of an inhibitor of the interaction between Excision Repair Cross\u2010Complementing Rrodent repair deficiency complementation group 1 (ERCC1) and Xeroderma Pigmentousum group F (XPF) (\n                      <jats:bold>B9<\/jats:bold>\n                      ), two key proteins of nucleotide excision repair.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We used various cell lines and co\u2010incubation studies for the determination of cell survival and DNA repair capacities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We show that it is synergistic with other platinum derivatives than previously described, and that synergy is lacking in cells not expressing ERCC1 or XPF. Finally, a series of experiments show that potentiation is observed only in cells expressing wild\u2010type p53.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our results confirm the mechanism of action of our ERCC1\u2013XPF inhibitor and give important additional data on this approach to enhance the activity of already existing cancer drugs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/fcp.13043","type":"journal-article","created":{"date-parts":[[2024,11,9]],"date-time":"2024-11-09T02:23:58Z","timestamp":1731119038000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The synergy between alkylating agents and ERCC1\u2013XPF inhibitors is p53 dependent"],"prefix":"10.1111","volume":"39","author":[{"given":"Gloria","family":"Ciniero","sequence":"first","affiliation":[{"name":"PolitoBIOMedLab, Department of Mechanical and Aerospace Engineering Politecnico di Torino  Turin Italy"},{"name":"Centre de Recherche en Canc\u00e9rologie de Lyon, INSERM U\u20101052, CNRS 5286, Centre L\u00e9on B\u00e9rard Universit\u00e9 Claude Bernard Lyon 1  Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiago Marques","family":"Pedro","sequence":"additional","affiliation":[{"name":"Centre de Recherche en Canc\u00e9rologie de Lyon, INSERM U\u20101052, CNRS 5286, Centre L\u00e9on B\u00e9rard Universit\u00e9 Claude Bernard Lyon 1  Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles","family":"Dumontet","sequence":"additional","affiliation":[{"name":"Centre de Recherche en Canc\u00e9rologie de Lyon, INSERM U\u20101052, CNRS 5286, Centre L\u00e9on B\u00e9rard Universit\u00e9 Claude Bernard Lyon 1  Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed H.","family":"Elmenoufy","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Alberta  Edmonton AB Canada"},{"name":"Department of Pharmaceutical Chemistry, College of Pharmacy Misr University for Science and Technology  6th of October City Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frederick G.","family":"West","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Alberta  Edmonton AB Canada"},{"name":"Cancer Research Institute of Northern Alberta University of Alberta  Edmonton AB Canada"},{"name":"Department of Oncology, Cross Cancer Institute University of Alberta  Edmonton AB Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Weinfeld","sequence":"additional","affiliation":[{"name":"Cancer Research Institute of Northern Alberta University of Alberta  Edmonton AB Canada"},{"name":"Department of Oncology, Cross Cancer Institute University of Alberta  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