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Nausea commonly occurs as an adverse effect of dopaminergic drugs in Parkinson's disease (PD) patients, with few alternative anti\u2010emetic options. This study aimed to assess domperidone prescription patterns in French PD patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this multicenter study, all consecutive PD patients from participating expert centers, hospitals, and private neurologists were included. We documented demographics, clinical data, comorbidities, domperidone use (indication, dose, and duration), and concurrent medications (related to PD or not). Domperidone misuse was assessed based on EMA guidelines.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Between January and October 2021, 1579 patients from 16 centers (12 French PD expert centers, two general hospitals, and two private practice neurologists) were included. Among them, 109 (7%) received domperidone: 32 (29%) for nausea during apomorphine infusion, 71 (65%) for nausea during other dopaminergic therapies, and three (3%) for orthostatic hypotension. Domperidone misuse was found in 103 patients (95%): treatment duration &gt;7\u00a0days (84%), age &gt;60\u2009years (79%), contraindicated drug interactions (6%), and contraindications due to cardiac comorbidity (5%). Only one patient exceeded the recommended dose (30\u2009mg\/day).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Domperidone is still prescribed in France for PD patients with dopaminergic\u2010induced nausea, mostly disregarding EMA guidelines due to patient age (&gt;60\u2009years) and prolonged treatment (&gt;7\u00a0days). Our study underscores the unmet need for managing gastrointestinal symptoms in PD, highlighting the inadequacy of EMA guidelines in this population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/fcp.70002","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T03:44:35Z","timestamp":1741751075000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Use and misuse of domperidone in patients living with Parkinson disease in France"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0108-4720","authenticated-orcid":false,"given":"Edouard","family":"Januel","sequence":"first","affiliation":[{"name":"D\u00e9partement de Sant\u00e9 Publique, Centre de Pharmaco\u00e9pid\u00e9miologie (Cephepi), Unit\u00e9 de Recherche Clinique PSL\u2010CFX, CIC\u20101901 Sorbonne Universit\u00e9, INSERM, Institut Pierre Louis d'Epid\u00e9miologie et de Sant\u00e9 Publique, \u00e9quipe 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