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A single dose of STZ (i.e., 75\u2009mg\/kg; i.p.) was administered to induce diabetes\u2010associated neuropathic pain in rats. The serum glucose level was estimated on days 0, 3, 42, and 45. A battery of behavioral tests, i.e., hot plate, plantar, tail immersion, and tail flick tests, were performed to assess the degree of thermal hyperalgesia in the paw and tail regions at different time intervals, i.e., 42nd and 44th day. Total protein, thiobarbituric acid reactive substances (TBARS), nitrite, reduced glutathione (GSH), and total calcium levels in sciatic nerve tissue were also estimated on the 45th day of the experiment. The test compound (CHO; 5, 10, or 15\u2009mg\/kg; p.o.) and pregabalin (10\u2009mg\/kg; p.o.) were administered for three consecutive days beginning on the 42nd day after STZ administration. STZ significantly induced diabetic neuropathic pain, as indicated by thermal hyperalgesia in the paw and tail along with increases in the TBARS, nitrite, and total calcium levels and a decrease in the GSH level. Administration of CHO attenuated STZ\u2010induced behavioral and biochemical changes in a dose\u2010dependent manner compared to those in the pregabalin\u2010treated group. The attenuating effect of CHO (15\u2009mg\/kg) on STZ\u2010induced diabetic neuropathic pain may be attributed to its neuroprotective potential via multiple pharmacological actions, including anti\u2010lipid peroxidation, free radical scavenging, and inhibition of intracellular calcium accumulation.<\/jats:p>","DOI":"10.1111\/fcp.70026","type":"journal-article","created":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T07:19:15Z","timestamp":1748330355000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Therapeutic Potential of 3\u2010(4\u2010Chlorophenyl)\u20104\u2010(2\u2010Hydroxyphenyl) 1,3\u2010Oxazetidin\u20102\u2010One in STZ\u2010Induced Diabetic Neuropathic Pain in Rats"],"prefix":"10.1111","volume":"39","author":[{"given":"Manpreet","family":"Kaur","sequence":"first","affiliation":[{"name":"Department of Chemistry Mata Gujri College  Fatehgarh Sahib Punjab India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dhruva","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Chemistry Guru Nanak College  Budhlada Punjab India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Navjeet","family":"Kaur","sequence":"additional","affiliation":[{"name":"Department of Physics Mata Gujri College  Fatehgarh Sahib Punjab India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.\u00a0M.","family":"Muthuraman","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Akal Toxicology Research Centre Akal College of Pharmacy &amp; Technical Education  Sangrur Punjab India"},{"name":"Toxicology and Basic Health Sciences Unit, Faculty of Pharmacy AIMST University  Bedong Kedah Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4449-9072","authenticated-orcid":false,"given":"Sushma","family":"Devi","sequence":"additional","affiliation":[{"name":"Chitkara College of Pharmacy Chitkara University  Rajpura"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7723-4487","authenticated-orcid":false,"given":"Saurabh","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Microbiology Mata Gujri College  Fatehgarh Sahib Punjab India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,5,27]]},"reference":[{"key":"e_1_2_12_2_1","first-page":"666","article-title":"A Brief Review on Recent Synthesis of 2\u2010Azetidinone Derivatives","volume":"5","author":"Salunkhe D.","year":"2014","journal-title":"IJPSR"},{"key":"e_1_2_12_3_1","first-page":"83","article-title":"N\u2010Substituted\u20103\u2010Chloro\u20102\u2010Azetidinones: Synthesis and Characterization of new Novel Anti\u2010Inflammatory Agents","volume":"1","author":"Vijay Kumar M.","year":"2009","journal-title":"Journal of Pharmaceutical Sciences and Research"},{"key":"e_1_2_12_4_1","first-page":"464","article-title":"Synthesis and Pharmacological Screening of Some New Azetidinone Derivatives","volume":"4","author":"Pawar P.","year":"2012","journal-title":"International Journal of Pharmacy and Pharmaceutical Sciences"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2008.09.033"},{"key":"e_1_2_12_6_1","first-page":"1","article-title":"Synthesis, Antioxidant, Antimicrobial, Antimycobacterial, and Cytotoxic Activities of Azetidinone and Thiazolidinone Moieties Linked to Indole Nucleus","volume":"2013","author":"Saundane A.","year":"2012","journal-title":"Journal of Chemistry"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm400311n"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carpath.2012.05.006"},{"key":"e_1_2_12_9_1","first-page":"369","article-title":"The Antioxidative Properties of Thiazolidine Derivatives","volume":"41","author":"Wlodek L.","year":"1989","journal-title":"Polish Journal of Pharmacology and Pharmacy"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.2478\/v10161-011-0066-4"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(93)90059-X"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.33549\/physiolres.930111"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.4161\/rna.20162"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1472-8206.2009.00801.x"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmn.2004.10.002"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)01307-0"},{"key":"e_1_2_12_17_1","first-page":"S1","article-title":"Classification of Chronic Pain. 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