{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T05:22:51Z","timestamp":1792041771378,"version":"4.4.0"},"reference-count":50,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T00:00:00Z","timestamp":1750377600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Fundamemntal Clinical Pharma"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The search for new treatments for sepsis is a pivotal subject of survey owing to the high mortality of sepsis. Sepsis can cause serious injury to many vital organs, including the liver. This study investigated the potential therapeutic impacts of fluvoxamine (FLV) against liver injury in a lipopolysaccharide (LPS)\u2010induced sepsis model. Thirty\u2010two female Wistar Albino rats were divided into four equal groups: control, LPS (5\u2009mg\/kg, i.p., single dose), LPS\u2009+\u2009FLV(5\u2009mg\/kg, i.p., single dose+50\u2009mg\/kg, i.p., single dose, 30\u2009min before LPS application) and FLV(50\u2009mg\/kg, i.p., single dose). Six hours after LPS application, blood and liver tissues were gathered under anesthesia for biochemical, histopathological, and immunohistochemical analyses. The RT\u2010qPCR analyzed the mRNA expression of nuclear factor erythroid 2\u2013related factor 2 (Nrf2), glycogen synthase kinase\u20103 (GSK3\u00df), kelch\u2010like ECH\u2013associated protein 1 (Keap1), and heme oxygenase\u20101 (HO\u20101). LPS administration caused significant histopathological changes in the liver and increased oxidative stress. It increased the number of TNF\u2010\u03b1, osteopontin (OPN), and serum amyloid A (SAA) immune positive cells associated with inflammation and decreased Nrf2, GSK3\u00df, Keap1, and HO\u20101 gene expressions associated with antioxidant defense. Additionally, serum alanine aminotransferase (ALT) level significantly increased. In the LPS\u2009+\u2009FLV and FLV groups, improvement in histopathological findings and a significant decrease in oxidative stress were detected. TNF\u2010\u03b1, OPN, and SAA expression decreased, and Nrf2, GSK3\u00df, Keap1, and HO\u20101 gene expressions increased. The decrease in serum aspartate aminotransferase (AST) and ALT was found to be significant only in the FLV group. Our findings therefore provide new evidence that FLV reduces LPS\u2010induced liver injury.<\/jats:p>","DOI":"10.1111\/fcp.70031","type":"journal-article","created":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T11:50:49Z","timestamp":1750420249000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Fluvoxamine Attenuates Liver Injury in Lipopolysaccharide\u2010Induced Sepsis: Via Nrf2\/HO\u20101 Pathway"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9516-0864","authenticated-orcid":false,"given":"Rahime","family":"Aslankoc","sequence":"first","affiliation":[{"name":"Department of Physiology, Faculty of Medicine S\u00fcleyman Demirel University  Isparta 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