{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T13:35:33Z","timestamp":1764509733873,"version":"3.46.0"},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T00:00:00Z","timestamp":1753833600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Fundamemntal Clinical Pharma"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Most of the drugs used in the treatment of cardiovascular diseases cause unfavorable effects on erectile functions. In this study, the effect of atorvastatin and gemfibrozil, which have different hypolipidemic mechanisms of action, on the erectile functions observed in mouse corpus cavernosum tissues is evaluated in\u00a0vitro. Mouse corpus cavernosum tissues are dissected under ketamine and xylazine anesthesia. Vessels were suspended in 30\u2009mL organ baths filled with Krebs solution and aerated with carbogen (95% O\n                    <jats:sub>2<\/jats:sub>\n                    , 5% CO\n                    <jats:sub>2<\/jats:sub>\n                    ) at 37\u00b0C. An initial tension of 500\u2009mg was applied to the suspended tissue strips. After a stabilization period of 90\u2009min, the protocols were applied to the tissue. Atorvastatin and gemfibrozil showed no direct contractile or relaxant effect on corpus cavernosum tissues. Both drugs caused a dose\u2010dependent relaxation in tissues precontracted with phenylephrine. Although the relaxant effect of atorvastatin is inhibited 40% by N\u2010nitro\u2010L\u2010arginine methyl ester (L\u2010NAME), these relaxations are totally inhibited by atropine. The relaxations caused by gemfibrozil are inhibited both by L\u2010NAME and atropine. No change was observed in responses of the tissues to acetylcholine, nitroprusside, and electrical field stimulation when incubated with atorvastatin or gemfibrozil. As a conclusion, both drugs showed similar effects on corpus cavernosum tissues. Atorvastatin and gemfibrozil caused these effects via endothelial nitric oxide. When all the results are evaluated, not only did the two drugs show no unfavorable effects, but they may also have some beneficial effects on erectile functions.\n                  <\/jats:p>","DOI":"10.1111\/fcp.70042","type":"journal-article","created":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T06:04:43Z","timestamp":1753941883000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of Atorvastatin and Gemfibrozil on Mice Corpus Cavernosum In\u00a0Vitro"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7168-9894","authenticated-orcid":false,"given":"Ilknur","family":"Erkoseoglu","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Department of Pharmacology Karadeniz Technical University  Trabzon Turkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mine\u00a0Kadioglu","family":"Duman","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Pharmacology Karadeniz Technical University  Trabzon Turkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabri\u00a0Murat","family":"Kesim","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Pharmacology Karadeniz Technical University  Trabzon Turkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ersin","family":"Yaris","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Pharmacology Karadeniz Technical University  Trabzon Turkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nuri\u00a0Ihsan","family":"Kalyoncu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Pharmacology Karadeniz Technical University  Trabzon Turkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,7,30]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-1241.2010.02563.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/fampra\/19.1.95"},{"issue":"6","key":"e_1_2_8_4_1","first-page":"1","article-title":"Impact of Atorvastatin on Erectile Dysfunction. 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