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The rising prevalence of antifungal resistance and virulence factors of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Candida albicans<\/jats:italic>\n                    <\/jats:styled-content>\n                    underscore the limitations of current therapies. Statins, commonly used as lipid\u2010lowering agents, have emerged as attractive repurposed drug candidates due to their ability to interfere with fungal ergosterol biosynthesis and Ras\u2010mediated signaling pathways. However, repurposed statins face major translational barriers, including poor water solubility, limited mucosal bioavailability, and dose\u2010dependent systemic toxicity. Nanotechnology\u2010driven delivery platforms offer versatile solutions to these challenges, enabling site\u2010directed delivery, improved stability, enhanced permeability, and controlled release. Lipid and polymeric nanocarriers, particularly chitosan\u2010based nanoparticles, enable controlled release and prolonged mucosal retention, making them suitable for localized antifungal therapy. This review explores the integration of statin repurposing with advanced drug delivery strategies as a novel therapeutic paradigm for mucosal candidiasis. Updated evidence demonstrating the antifungal potential of nano\u2010formulated statins is summarized, in conjunction with a general overview of design aspects relevant to optimizing delivery systems. Although still in early stages of investigation, this synergistic approach holds promise for overcoming resistance mechanisms and reducing the recurrence rates associated with existing antifungals. Ultimately, leveraging drug repurposing alongside nanotechnology may accelerate the translation of statin\u2010based antifungal therapies into clinical practice, providing an innovative and cost\u2010effective avenue to broaden the therapeutic arsenal against mucosal\n                    <jats:italic>Candida<\/jats:italic>\n                    infections.\n                  <\/jats:p>","DOI":"10.1111\/fcp.70046","type":"journal-article","created":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T03:17:27Z","timestamp":1757560647000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Statins as Antifungal Agents: A Review on Drug Repurposing and Nanotechnology\u2010Driven Delivery Strategies"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-7641-8405","authenticated-orcid":false,"given":"Dominique\u00a0Mesquita","family":"e 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