{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T23:15:12Z","timestamp":1773098112392,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T00:00:00Z","timestamp":1765497600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T00:00:00Z","timestamp":1765497600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Fundamemntal Clinical Pharma"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Neuropathic pain remains a complex condition to manage. While current literature provides best practice guidelines for the use of gabapentinoids in this indication, these recommendations are primarily based on randomised clinical trials (RCTs) and meta\u2010analyses of varying methodological quality. To support evidence\u2010based prescribing, we conducted an evaluation of the overall confidence in meta\u2010analytic findings on the efficacy of gabapentinoid in adults. A systematic review of the meta\u2010analyses of RCTs retrieved from the MEDLINE (PubMed) database was performed. The methodological quality of these meta\u2010analyses was assessed using the AMSTAR 2 tool (A MeaSurement Tool to Assess systematic Reviews) and compared when available with the quality of evidence determined by the GRADE approach. Among the 16 included meta\u2010analyses, 14 were rated as having \u2018critically low\u2019 quality, one as \u2018low\u2019 and one as \u2018moderate\u2019 according to AMSTAR 2. GRADE and AMSTAR 2 assessments were both available for six meta\u2010analyses, but only one yielded a concordant result. According to AMSTAR 2, the highest\u2010quality meta\u2010analysis was the one published in the Cochrane Database of Systematic Reviews and concluded that more participants had substantial benefit (at least 50% pain relief or patient global impression change very much improved) with gabapentin at 1200\u2009mg daily or greater than with placebo (in postherpetic neuralgia: RR\u2009=\u20091.8 [95% CI 1.5 to 2.1] and in painful diabetic neuropathy: RR\u2009=\u20091.9 [95% CI 1.5 to 2.3]). One limitation of this work is the inconsistent use of the term neuropathic pain, which may be defined differently across studies.<\/jats:p>","DOI":"10.1111\/fcp.70052","type":"journal-article","created":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T17:44:40Z","timestamp":1765561480000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Gabapentinoids and Neuropathic Pain: Evaluation of the Quality of Randomised Controlled Trials: An Umbrella Review"],"prefix":"10.1111","volume":"40","author":[{"given":"Humbert","family":"de Freminville","sequence":"first","affiliation":[{"name":"Coll\u00e8ge Universitaire de M\u00e9decine G\u00e9n\u00e9rale UCBL Lyon 1  Lyon France"},{"name":"RESHAPE, Inserm U1290  Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Lucatelli","sequence":"additional","affiliation":[{"name":"Coll\u00e8ge Universitaire de M\u00e9decine G\u00e9n\u00e9rale UCBL Lyon 1  Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Chaneli\u00e8re","sequence":"additional","affiliation":[{"name":"Coll\u00e8ge Universitaire de M\u00e9decine G\u00e9n\u00e9rale UCBL Lyon 1  Lyon France"},{"name":"UMR 5558, LBBE, EMET, CNRS Universit\u00e9 Claude Bernard Lyon 1  Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillaume","family":"Grenet","sequence":"additional","affiliation":[{"name":"P2S, UR 4129 Universit\u00e9 Claude Bernard Lyon 1  Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabine","family":"Mainbourg","sequence":"additional","affiliation":[{"name":"P2S, UR 4129 Universit\u00e9 Claude Bernard Lyon 1  Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8918-3186","authenticated-orcid":false,"given":"R\u00e9my","family":"Boussageon","sequence":"additional","affiliation":[{"name":"Coll\u00e8ge Universitaire de M\u00e9decine G\u00e9n\u00e9rale UCBL Lyon 1  Lyon France"},{"name":"P2S, UR 4129 Universit\u00e9 Claude Bernard Lyon 1  Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,12]]},"reference":[{"key":"e_1_2_13_2_1","unstructured":"H.MerskeyandN.Bogduk(2011).Terminology Neuropathic Pain. International Retrieved fromhttps:\/\/www.iasp\u2010pain.org\/resources\/terminology\/."},{"key":"e_1_2_13_3_1","unstructured":"N.Attal F.Aubrun andN.Authier et\u00a0al. 2017.Livre Blanc de la Douleur. SFETD; Retrieved fromhttps:\/\/www.sfetd\u2010douleur.org\/wp\u2010content\/uploads\/2019\/09\/livre_blanc\u20102017\u201010\u201024.pdf."},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2007.08.013"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.3166\/dea\u20102020\u20100113"},{"key":"e_1_2_13_6_1","volume-title":"Neuropathic Pain in Adults: Pharmacological Management in Non\u2010Specialist Settings; Clinical Guidelines","author":"National Institute for Health and Care Excellence","year":"2020"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468\u20101331.2006.01511.x"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen\u20102018\u2010023600"},{"key":"e_1_2_13_9_1","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions Version 6.3 (Updated February 2022)","author":"Sch\u00fcnemann H. 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