{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T05:51:37Z","timestamp":1782280297191,"version":"3.54.5"},"reference-count":9,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T00:00:00Z","timestamp":1765411200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T00:00:00Z","timestamp":1765411200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100020147","name":"European Network for Rare Adult Solid Cancers","doi-asserted-by":"publisher","award":["739521"],"award-info":[{"award-number":["739521"]}],"id":[{"id":"10.13039\/501100020147","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Fundamemntal Clinical Pharma"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>DEEPSARC, one of the first projects running on the Health Data Hub, aimed to identify real\u2010life treatment regimens that could improve overall survival. The project is based on matching the national database of the sarcoma reference network with the SNDS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>We aimed to report a transparent description of the linking process and its results.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The sarcoma database encompasses 33\u2009548 patients matching the selection criteria divided into three subsets: 13507 patients with a complete dataset gathering clinical and pathological data; 5844 patients with clinical data alone; and 14\u2009197 patients with pathological data alone. As no ICD\u201010 code reliably identifies patients with sarcoma, the subpopulation extracted from the SNDS was extended to 3 million patients who underwent surgery for their cancer. An indirect record linkage process used a combination (called a signature) of so\u2010called chaining variables to uniquely identify a pair of patients from each of the bases. Two metrics (signature robustness and overall quality) were calculated for ease of interpretation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The overall matching rate of 73.1% (24\u2009539 pairs out of 33\u2009548 observations), reaching 90.5% in the intersection of the sarcomas databases (with extended data, 12\u2009225 pairs out of 13\u2009507 observations).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>An optimized and transparent process led to a moderate matching rate but enhanced the confidence in true matching. Representativeness is an issue related to the missing data pattern across the three NETSARC databases. For instance, an individual present only in the RREPS database has a greater probability of not being linked.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/fcp.70066","type":"journal-article","created":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T00:50:07Z","timestamp":1765500607000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Linking the NETSARC+ National Sarcoma Database With the SNDS to Evaluate Adjuvant and\/or Neoadjuvant Therapy: Report on the Linkage Process and Result (Health Data Hub's DEEPSARC Pilot Project)"],"prefix":"10.1111","volume":"40","author":[{"given":"Erwan","family":"Drezen","sequence":"first","affiliation":[{"name":"CUBR SAS  Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Happe","sequence":"additional","affiliation":[{"name":"University of Rennes  Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Thevenet","sequence":"additional","affiliation":[{"name":"INSERM, Institut Bergoni\u00e9, CIC 1401, Euclid\/F\u2010CRIN Clinical Trials Platform University of Bordeaux  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Penel","sequence":"additional","affiliation":[{"name":"Medical Oncology Department Oscar Lambret Cancer Center and Lille University  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Gouin","sequence":"additional","affiliation":[{"name":"Centre L\u00e9on B\u00e9rard University Claude Bernard Lyon I  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Le\u00a0Loarer","sequence":"additional","affiliation":[{"name":"Institut Bergoni\u00e9 University of Bordeaux  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gonzague","family":"Du\u00a0Bouexic\u00a0De\u00a0Pinieux","sequence":"additional","affiliation":[{"name":"CHU Tours University of Tours  Tours France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugo","family":"Crochet","sequence":"additional","affiliation":[{"name":"Centre L\u00e9on B\u00e9rard University Claude Bernard Lyon I  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire\u00a0Chemin","family":"Airiau","sequence":"additional","affiliation":[{"name":"Centre L\u00e9on B\u00e9rard University Claude Bernard Lyon I  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7oise","family":"Ducimetiere","sequence":"additional","affiliation":[{"name":"Centre L\u00e9on B\u00e9rard University Claude Bernard Lyon I  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Mathoulin\u00a0Pelissier","sequence":"additional","affiliation":[{"name":"INSERM, Institut Bergoni\u00e9, CIC 1401, Bordeaux Population Health U1219 Epicene Team University of Bordeaux  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Yves","family":"Blay","sequence":"additional","affiliation":[{"name":"Department of Medicine L\u00e9on B\u00e9rard Center  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9837-2977","authenticated-orcid":false,"given":"Emmanuel","family":"Oger","sequence":"additional","affiliation":[{"name":"University of Rennes  Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,11]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdr610"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdx484"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2024.01.001"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14112620"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.respe.2017.05.004"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.therap.2018.09.072"},{"key":"e_1_2_11_8_1","article-title":"Challenges of Using ICD\u20109\u2010CM and ICD\u201010\u2010CM. Codes for Soft\u2010Tissue Sarcoma in Databases for Health Services Research","volume":"16","author":"Hess L. 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