{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T04:08:49Z","timestamp":1779422929684,"version":"3.53.1"},"reference-count":48,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T00:00:00Z","timestamp":1776556800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T00:00:00Z","timestamp":1776556800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Fundamemntal Clinical Pharma"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Iohexol clearance (mGFR\n                      <jats:sub>ioh<\/jats:sub>\n                      ) is a marker of choice for measuring glomerular filtration rate (GFR) in potential living kidney donors.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      We studied (1) the determinants of mGFR\n                      <jats:sub>ioh<\/jats:sub>\n                      variation among kidney donors before and 1\u2009year after donation and (2) the impact of donor mGFR\n                      <jats:sub>ioh<\/jats:sub>\n                      change on the gain in estimated GFR 3\u2009months after transplantation in kidney transplant recipients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We performed a retrospective, monocentric study in couples of living kidney donors\/transplant recipients. In donors, mGFR\n                      <jats:sub>ioh<\/jats:sub>\n                      was measured before and 1\u2009year after donation and calculated using the slope\u2010intercept method and the Br\u00f6chner\u2010Mortensen correction. In recipients, eGFR was calculated by the CKD\u2010EPI formula before and 3\u2009months after transplantation. Determinants of mGFR\n                      <jats:sub>ioh<\/jats:sub>\n                      change in donors and eGFR change in recipients were studied using univariate and multivariate general linear models.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Sixty\u2010nine kidney donors (41 women), with a median age of 56\u2009years, were included. The median (10th\u201390th percentiles) decrease in mGFR\n                      <jats:sub>ioh<\/jats:sub>\n                      at 1 year post\u2010donation was 29.7% (13.9\u201343.0). Determinants of a greater mGFR\n                      <jats:sub>ioh<\/jats:sub>\n                      decline (estimate; standard deviation) included female sex (\u22129.8; 3.3), older age (\u22120.43; 0.14), and high pre\u2010donation mGFR\n                      <jats:sub>ioh<\/jats:sub>\n                      value (\u22120.24; 0.07). Smoking status and body mass index were not associated with mGFR\n                      <jats:sub>ioh<\/jats:sub>\n                      decrease. In kidney recipients, the gain in eGFR\n                      <jats:sub>CKD\u2010EPI<\/jats:sub>\n                      at 3\u2009months post\u2010transplantation was not correlated to mGFR\n                      <jats:sub>ioh<\/jats:sub>\n                      variation (before vs. 1\u2009year post\u2010donation) of donors.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Our data identified female sex and age as key determinants of mGFR\n                      <jats:sub>ioh<\/jats:sub>\n                      at 1\u2009year post\u2010donation. Donor mGFR\n                      <jats:sub>ioh<\/jats:sub>\n                      pre\u2010donation or mGFR\n                      <jats:sub>ioh<\/jats:sub>\n                      change 1\u2009year after donation had no impact on early recipient kidney graft function.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/fcp.70087","type":"journal-article","created":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T23:13:57Z","timestamp":1776640437000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Iohexol Clearance and Kidney Transplantation: Determinants of Its Variation in Living Kidney Donors One Year After Donation and Impact on Glomerular Filtration Rate Gain in Kidney Recipients"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-2048-2154","authenticated-orcid":false,"given":"Capucine","family":"Arriv\u00e9","sequence":"first","affiliation":[{"name":"Univ. Grenoble Alpes, HP2 INSERM U1300  Grenoble France"},{"name":"Laboratory of Pharmacology, Pharmacogenetics and Toxicology Grenoble Alpes University Hospital  Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan","family":"Baran","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacology, Pharmacogenetics and Toxicology Grenoble Alpes University Hospital  Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Tonini","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacology, Pharmacogenetics and Toxicology Grenoble Alpes University Hospital  Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Jouve","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Dialysis, Apheresis and Transplantation Grenoble Alpes University Hospital  Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7oise","family":"Stanke\u2010Labesque","sequence":"additional","affiliation":[{"name":"Univ. Grenoble Alpes, HP2 INSERM U1300  Grenoble France"},{"name":"Laboratory of Pharmacology, Pharmacogenetics and Toxicology Grenoble Alpes University Hospital  Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,19]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003\u20104819\u2010145\u20104\u2010200608150\u201000004"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000180580"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnmt.113.121004"},{"key":"e_1_2_13_5_1","unstructured":"\u201cOmnipaque (Iohexol)\u2014Summary of Product Characteristics\u2014Food and Drug Administration \u201d (2017) https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2017\/018956s099lbl.pdf."},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0022\u20105347(17)37891\u20106"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/ckj\/sfw071"},{"key":"e_1_2_13_8_1","unstructured":"Council of Europe European Committee on Organ Transplantation \u201cInternational Figures on Organ Tissue & Haematopoietic Stem Cell Donation & Transplantation Activities \u201d Newsletter Transplant (2018):https:\/\/www.europarl.europa.eu\/EPRS\/Newsletter_Transplant_2019.pdf."},{"key":"e_1_2_13_9_1","unstructured":"Agence de la Biom\u00e9decine \u201cRecommandations Formalis\u00e9es d'Experts sur le Pr\u00e9l\u00e8vement et le Greffe \u00e0 Partir de Donneur Vivant \u201d (2009). 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