{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T04:08:49Z","timestamp":1779422929662,"version":"3.53.1"},"reference-count":57,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T00:00:00Z","timestamp":1776902400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T00:00:00Z","timestamp":1776902400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Fundamemntal Clinical Pharma"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The objective of this study is to evaluate the influence of alogliptin treatment on the healing process of traumatic oral ulcers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Four experimental groups were used: control group (GC) and three test groups treated with oral Alogliptin at 1 (GTA1), 3 (GTA3), and 9\u2009mg\/kg\/day (GTA9). Ulcer diameter, body weight, glycemic index, colony\u2010forming unit (CFU), and discomfort were analyzed. Histological slides were prepared for healing scores, inflammatory cell counts, collagen deposition analysis, and immunohistochemistry.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Alogliptin treatment increased ulcer area (GTA3\u20107D: 5.2\u2009\u00b1\u20091.2; GTA9\u20103D: 11.8\u2009\u00b1\u20090.8; GTA9\u20107D: 5.8\u2009\u00b1\u20091.3;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), CFU counts (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.049), and Grimace\/discomfort scores (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02), while reducing body weight gain (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.007) in GTA3 and GTA9 groups. Microscopic analysis revealed higher histopathological scores (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.039), increased mononuclear cells (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.006), reduced polymorphonuclear cells (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05), and decreased collagen deposition (18.2\u2009\u00b1\u20092.6;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.031) in GTA9. Lower TLR4 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001) and TGF\u2010\u03b2 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) expression, alongside increased CD31 immunostaining (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), were observed in GTA3 and GTA9, as well as reduced TLR2 expression (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001) in GTA9.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Alogliptin delays oral ulcer healing by sustaining inflammation, reducing TGF\u2010\u03b2 expression, and impairing collagen deposition, and may contribute via reduced TLR2\/TLR4 expression, increased microbial burden, and decreased TGF\u2010\u03b2.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/fcp.70090","type":"journal-article","created":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T00:10:10Z","timestamp":1776989410000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Alogliptin Delays the Healing of Traumatic Oral Ulcers in the Buccal Mucosa of Wistar Rats"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0272-606X","authenticated-orcid":false,"given":"Maria\u00a0Imaculada","family":"de Queiroz\u00a0Rodrigues","sequence":"first","affiliation":[{"name":"Department of Dental Clinic, Stomatology and Oral Pathology Sector, School of Pharmacy, Dentistry and Nursing Federal University of Ceara  Fortaleza Cear\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joyce\u00a0Ohana","family":"de Lima\u00a0Martins","sequence":"additional","affiliation":[{"name":"Department of Dental Clinic, Stomatology 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