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Nebivolol is a third\u2010generation \u03b2\u2010blocker that exerts vasculoprotective effects in obesity. The thoracic and abdominal aorta show different responses under physiological conditions, and their PVATs have a distinctive composition and secretory profile. We hypothesized that obesity would affect thoracic and abdominal aortic responsiveness, as well as their PVAT function, differently and that nebivolol would restore obesity\u2010induced vascular and PVAT changes. To test this hypothesis, male Wistar Hannover rats were fed a hypercaloric diet for 14\u2009weeks. Nebivolol (10\u2009mg\/kg\/day) was administered via gavage during the last 4\u2009weeks. Obesity increased superoxide (O\n                    <jats:sub>2<\/jats:sub>\n                    \u2022\n                    <jats:sup>\u2212<\/jats:sup>\n                    ) generation within the thoracic PVAT, but this response did not result in a loss of its anticontractile effect. Vascular hypercontractility was detected in thoracic aortas, which was mediated by the overproduction of NADPH oxidase\u2010derived O\n                    <jats:sub>2<\/jats:sub>\n                    \u2022\n                    <jats:sup>\u2212<\/jats:sup>\n                    and reduced nitric oxide (NO) bioavailability. Conversely, obesity induced a pro\u2010contractile phenotype in the PVAT of the abdominal aorta. This response occurred in an endothelium\u2010dependent manner, was ameliorated by tiron, and was accompanied by increased O\n                    <jats:sub>2<\/jats:sub>\n                    \u2022\n                    <jats:sup>\u2212<\/jats:sup>\n                    levels. In all cases, nebivolol reversed the effects of obesity. In summary, obesity differentially affects the thoracic and abdominal aorta and their respective PVATs. Nebivolol exerts vasculoprotective effects through antioxidant mechanisms, leading to a reversal of obesity\u2010induced vascular hypercontractility in both aortic segments. The beneficial effects of nebivolol described here could help mitigate cardiovascular complications associated with obesity. Obesity induces PVAT dysfunction. Extending this knowledge, we demonstrated that obesity differentially affects the thoracic and abdominal aorta along with their associated PVATs. This widespread impairment of PVAT function can drive various adverse vascular consequences, including arterial hypertension and aneurysm formation. Critically, peri\u2010aortic PVAT is of particular clinical relevance due to its association with metabolic risk factors and vascular calcification. Nebivolol exerts vasculoprotective effects via antioxidant mechanisms within PVAT, ultimately reversing obesity\u2010induced vascular hypercontractility in both aortic segments. Thus, investigating pharmacological agents that restore PVAT function, as demonstrated here with nebivolol, represents a promising therapeutic strategy to mitigate obesity\u2010related cardiovascular complications.\n                  <\/jats:p>","DOI":"10.1111\/fcp.70096","type":"journal-article","created":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T23:00:24Z","timestamp":1781564424000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Nebivolol Protects the Thoracic and Abdominal Aorta and Their Perivascular Adipose Tissue From the Differential Detrimental Effects of Obesity"],"prefix":"10.1111","volume":"40","author":[{"given":"Thales M. H.","family":"Dourado","sequence":"first","affiliation":[{"name":"Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Farmacologia, Faculdade de Medicina de Ribeir\u00e3o Preto Universidade de S\u00e3o Paulo (USP)  Ribeir\u00e3o Preto S\u00e3o Paulo Brazil"},{"name":"Laborat\u00f3rio de Farmacologia Cardiovascular, Departamento de Ci\u00eancias BioMoleculares, Faculdade de Ci\u00eancias Farmac\u00eauticas de Ribeir\u00e3o Preto USP  Ribeir\u00e3o Preto S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo F.","family":"Pimenta","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Farmacologia, Faculdade de Medicina de Ribeir\u00e3o Preto Universidade de S\u00e3o Paulo (USP)  Ribeir\u00e3o Preto S\u00e3o Paulo Brazil"},{"name":"Laborat\u00f3rio de Farmacologia Cardiovascular, Departamento de Ci\u00eancias BioMoleculares, Faculdade de Ci\u00eancias Farmac\u00eauticas de Ribeir\u00e3o Preto USP  Ribeir\u00e3o Preto S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo P.","family":"Silva","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Farmacologia Cardiovascular, Departamento de Ci\u00eancias BioMoleculares, Faculdade de Ci\u00eancias Farmac\u00eauticas de Ribeir\u00e3o Preto USP  Ribeir\u00e3o Preto S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor O.","family":"Assis","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Farmacologia, Faculdade de Medicina de Ribeir\u00e3o Preto Universidade de S\u00e3o Paulo (USP)  Ribeir\u00e3o Preto S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra O.","family":"Silva","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Farmacologia Cardiovascular, Departamento de Ci\u00eancias BioMoleculares, Faculdade de Ci\u00eancias 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