{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T08:05:57Z","timestamp":1784793957996,"version":"3.55.0"},"reference-count":60,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T00:00:00Z","timestamp":1783987200000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Fundamemntal Clinical Pharma"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      Cardiovascular complications of diabetes mellitus (DM) are responsible for morbidity and mortality in DM patients. Recent evidence highlights the pathophysiological role of the renin\u2010angiotensin\u2010aldosterone system in DM. This study determined whether chronic angiotensin (1\u20137) (Ang (1\u20137); 576\u2009\u03bcg\/kg, s.c., 4\u2009weeks) treatment improves vascular reactivity in mesenteric small resistance arteries of streptozotocin\u2010induced diabetic rats using a wire myograph system and to investigate the underlying mechanisms. Increased sensitivity to vasoconstrictors and decreased responses to endothelium\u2010dependent vasodilators in diabetic rats compared to control rats were partially reversed by Ang (1\u20137) treatment. N\u03c9\u2010nitro\u2010L\u2010arginine methyl ester (L\u2010NAME, 10\n                      <jats:sup>\u22124<\/jats:sup>\n                      \u2009M) incubation significantly decreased vasorelaxant responses to acetylcholine (ACH, 10\n                      <jats:sup>\u221210<\/jats:sup>\n                      \u201310\n                      <jats:sup>\u22125<\/jats:sup>\n                      \u2009M) in all groups except the diabetic group. Superoxide dismutase (SOD, 50\u2009U\/mL) incubation produced significant increases in vasorelaxant responses to ACH only in the diabetic groups. Glibenclamide (10\n                      <jats:sup>\u22125<\/jats:sup>\n                      \u2009M), 4\u2010aminopyridine (4\u2010AP, 5\u2009mM), indomethacin (INDO, 10\n                      <jats:sup>\u22125<\/jats:sup>\n                      \u2009M), or catalase (CAT, 200\u2009U\/mL) incubations did not alter ACH responses in any experimental groups, whereas charybdotoxin (ChTX, 10\n                      <jats:sup>\u22127<\/jats:sup>\n                      \u2009M) or apamin (APA, 10\n                      <jats:sup>\u22127<\/jats:sup>\n                      \u2009M) produced significant decreases in ACH\u2010induced vasorelaxation, similar in extent in the control and diabetic rats. Following co\u2010incubation with L\u2010NAME and INDO, ACH\u2010induced vasorelaxation in 30\u2009mM KCl pre\u2010contracted arterial rings did not differ significantly between the groups. These findings indicate that improved nitric oxide bioavailability and reduced superoxide activity contribute to the beneficial vascular effects of Ang (1\u20137) in diabetic rat resistance arteries. Further in\u00a0vivo studies are warranted to clarify its therapeutic relevance.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Summary<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Ang (1\u20137) improves vascular function in diabetic rat resistance arteries.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Treatment increases NO bioavailability and reduces oxidative stress.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Vasoconstrictor sensitivity is decreased, improving endothelium\u2010dependent vasorelaxation.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Ang (1\u20137) restores vascular responses to endogenous vasoactive agents.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Findings suggest Ang (1\u20137) as a potential target for diabetes\u2010related vascular issues.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/fcp.70107","type":"journal-article","created":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T08:11:31Z","timestamp":1784016691000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Effect of Chronic Angiotensin (1\u20137) Treatment on Functional Responses of Isolated Resistance Arteries in Streptozotocin\u2010Induced Diabetic Rats"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6238-8173","authenticated-orcid":false,"given":"Esra","family":"Akcabag","sequence":"first","affiliation":[{"name":"Medical Faculty, Department of Medical Pharmacology Akdeniz University  Antalya Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikbal Ozen","family":"Kucukcetin","sequence":"additional","affiliation":[{"name":"Medical Faculty, Department of Medical Biochemistry Akdeniz University  Antalya Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gul","family":"Ozbey","sequence":"additional","affiliation":[{"name":"Medical Faculty, Department of Medical Pharmacology Akdeniz University  Antalya Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebahat","family":"Ozdem","sequence":"additional","affiliation":[{"name":"Medical Faculty, Department of Medical Biochemistry Akdeniz University  Antalya 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