{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T06:54:38Z","timestamp":1790924078289,"version":"4.1.0"},"reference-count":45,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Fundamemntal Clinical Pharma"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The results of randomized controlled trials (RCTs) regarding the effect of vitamin D supplementation on mortality reduction are conflicting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The aim of this study was to assess the level of evidence through a sensitivity analysis of the meta\u2010analysis by Shah et\u00a0al. (2024) using the Rebuilt the Evidence Base (REB) method.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The main inclusion criterion was a double\u2010blind, placebo\u2010controlled RCT design. The exclusion criteria were trials combining vitamin D with other nutrients and unpublished RCTs. The main outcome was all\u2010cause mortality. A bias analysis was performed, followed by a hypothetico\u2010deductive analysis to determine the confirmatory or exploratory nature of each RCT. The REB method was used to interpret the results and assess the level of evidence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among the 25 RCTs included in the meta\u2010analysis by Shah et\u00a0al., the analysis was performed on 8 RCTs at low risk of bias including 30\u2009320 participants. Seven RCTs raised some concerns, and two RCTs were at high risk of bias according to ROB2. Bias arose from the randomization process, deviations from intended interventions, missing outcome data, and selection of the reported results. The results were statistically significant, in favor of vitamin D supplementation: RR\u2009=\u20090.96 (95% CI [0.92, 1.00]),\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.04. No RCT was conclusive.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>According to the REB method, there is an evidence signal regarding the benefit of vitamin D supplementation in the population aged 75 and older, which remains to be confirmed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/fcp.70112","type":"journal-article","created":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T06:31:50Z","timestamp":1790922710000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Vitamin D Supplementation and Mortality in the Elderly: A Review of a Meta\u2010Analysis of Randomized Controlled Trials Using the REB Method"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-2061-8937","authenticated-orcid":false,"given":"Natalia","family":"Kostakis","sequence":"first","affiliation":[{"name":"Coll\u00e8ge Universitaire de M\u00e9decine G\u00e9n\u00e9rale Universit\u00e9 Claude Bernard Lyon 1  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9398-2968","authenticated-orcid":false,"given":"Jean\u2010Christophe","family":"Lega","sequence":"additional","affiliation":[{"name":"\u00c9quipe \u00c9valuation et Mod\u00e9lisation des Effets Th\u00e9rapeutiques, Laboratoire de Biom\u00e9trie et Biologie Evolutive Universit\u00e9 Claude Bernard Lyon 1  Lyon France"},{"name":"Lyon Immunophathology Federation (LIFe) Hospices Civils de Lyon  Lyon France"},{"name":"Service Hospitalo\u2010Universitaire de Pharmacotoxicologie Hospices Civils de Lyon  Lyon France"},{"name":"Service de Rhumatologie, H\u00f4pital Lyon Sud Hospices Civils de Lyon  Pierre\u2010B\u00e9nite France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8918-3186","authenticated-orcid":false,"given":"Remy","family":"Boussageon","sequence":"additional","affiliation":[{"name":"Coll\u00e8ge Universitaire de M\u00e9decine G\u00e9n\u00e9rale Universit\u00e9 Claude Bernard Lyon 1  Lyon France"},{"name":"\u00c9quipe \u00c9valuation et Mod\u00e9lisation des Effets Th\u00e9rapeutiques, Laboratoire de Biom\u00e9trie et Biologie Evolutive Universit\u00e9 Claude Bernard Lyon 1  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,1]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgae290"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgae312"},{"key":"e_1_2_11_4_1","unstructured":"HAS \u2010 Direction de l'Evaluation et de l'Acc\u00e8s \u00e0 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