{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T14:49:49Z","timestamp":1791470989475,"version":"4.3.4"},"reference-count":38,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000},"content-version":"vor","delay-in-days":280,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Fundamemntal Clinical Pharma"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To investigate the influence of sex, age, body weight, smoking habits, and co\u2010medications on sertraline pharmacokinetics in a routine clinical setting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective observational study analyzed 177 predominantly inpatient therapeutic drug monitoring records from 101 patients receiving sertraline as monotherapy or polytherapy. Pharmacokinetic parameters\u2014serum concentrations (CSER), concentration\u2010to\u2010dose ratio (CDR), weight\u2010normalized CDR (CDR\/kg), apparent clearance (CL\/F), and metabolite\u2010to\u2010parent ratio (N\u2010SER\/SER)\u2014were compared across subgroups defined by sex, age (&lt;\u200918; 18\u201365; &gt;\u200965\u2009years), BMI, smoking, and co\u2010medications. To address the nonindependence of repeated measurements, analyses were complemented using linear mixed\u2010effects models and a sensitivity analysis restricted to one observation per patient.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Descriptive analyses suggested higher CDR\/kg in males and higher CSER in elderly patients. After accounting for within\u2010patient clustering, the increase in CDR\/kg across BMI categories remained the most consistent finding, likely reflecting mathematical normalization. The higher CSER observed in elderly patients persisted in the mixed\u2010effects model but not in the sensitivity analysis, although the direction of effect remained consistent. Sex\u2010related differences were not robust after adjustment and were largely attributable to body weight. Smoking showed no measurable effect. Among co\u2010medications, carbamazepine showed the most consistent pharmacokinetic signal, whereas other findings were less consistent.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Elderly age may contribute to higher sertraline concentrations; however, its effect appears modest after accounting for clustering. Sex differences are largely explained by body weight, and smoking does not appear to influence pharmacokinetics. Carbamazepine showed a consistent induction pattern, whereas other co\u2010medication findings should be considered exploratory.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/fcp.70114","type":"journal-article","created":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T13:53:27Z","timestamp":1791467607000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Variability in Sertraline Pharmacokinetics in Routine Clinical Practice: Influence of Sex, Age, Body Weight, Smoking, and Co\u2010Medication"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-4452-894X","authenticated-orcid":false,"given":"Bego\u00f1a","family":"Tapia\u2010Alzuguren","sequence":"first","affiliation":[{"name":"Pharmacy Service Cl\u00ednica Universidad de Navarra  Pamplona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-2349-3631","authenticated-orcid":false,"given":"Covadonga","family":"Canga\u2010Espina","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Clinical Psychology Cl\u00ednica Universidad de Navarra  Pamplona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9287-9635","authenticated-orcid":false,"given":"Patricio","family":"Molero","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Clinical Psychology Cl\u00ednica Universidad de Navarra  Pamplona Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria de Navarra (IdiSNA), Pamplona  Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azucena","family":"Aldaz","sequence":"additional","affiliation":[{"name":"Pharmacy Service Cl\u00ednica Universidad de Navarra  Pamplona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,8]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/da.22968"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.298"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100043\u2010116492"},{"key":"e_1_2_14_5_1","unstructured":"D. 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