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The normal and pathological growth of the prostate are both dependent on stimulation by dihydrotestosterone, which is synthesized from circulating testosterone by two 5\u03b1\u2010reductase (5\u03b1\u2010R) isozymes, 5\u03b1\u2010reductase type\u00a01 (5\u03b1\u2010R1) and 5\u03b1\u2010reductase type\u00a02 (5\u03b1\u2010R2). Both isozymes have been implicated in prostate disease. We used quantitative RT\u2010PCR and immunohistochemistry, respectively, to quantify <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> and protein levels of 5\u03b1\u2010R isozymes in the ventral prostate of adult rats under environmental stress conditions analogous to those found in some common workplace situations, i.e. artificial light, excessive heat, and the sensation of immobility in a small space. Transcription and expression levels of both 5\u03b1\u2010R isozymes were significantly higher in environmentally stressed rats than in unstressed rats. Increased 5\u03b1\u2010R isozyme levels may play a role in the development or maintenance of prostate disease. Further research is warranted to explore these effects of environmental stress on human health and their implications for environmental and occupational health policies.<\/jats:p>","DOI":"10.1111\/febs.12052","type":"journal-article","created":{"date-parts":[[2012,11,2]],"date-time":"2012-11-02T09:01:30Z","timestamp":1351846890000},"page":"93-101","source":"Crossref","is-referenced-by-count":7,"title":["Expression of steroid 5\u03b1\u2010reductase isozymes in prostate of adult rats after environmental stress"],"prefix":"10.1111","volume":"280","author":[{"given":"Pilar","family":"S\u00e1nchez","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Faculty of Medicine University of Granada Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jes\u00fas M.","family":"Torres","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Faculty of Medicine University of Granada 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