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This review focuses on their regulatory roles in matrix assembly.\n                    <jats:styled-content style=\"fixed-case\">SLRP<\/jats:styled-content>\n                    s have protein cores and hypervariable glycosylation with multivalent binding abilities. During development, differential interactions of\n                    <jats:styled-content style=\"fixed-case\">SLRP<\/jats:styled-content>\n                    s with other molecules result in tissue\u2010specific spatial and temporal distributions. The changing expression patterns play a critical role in the regulation of tissue\u2010specific matrix assembly and therefore tissue function.\n                    <jats:styled-content style=\"fixed-case\">SLRP<\/jats:styled-content>\n                    s play significant structural roles within extracellular matrices. In addition, they play regulatory roles in collagen fibril growth, fibril organization and extracellular matrix assembly. Moreover, they are involved in mediating cell\u2013matrix interactions. Abnormal\n                    <jats:styled-content style=\"fixed-case\">SLRP<\/jats:styled-content>\n                    expression and\/or structures result in dysfunctional extracellular matrices and pathophysiology. Altered expression of\n                    <jats:styled-content style=\"fixed-case\">SLRP<\/jats:styled-content>\n                    s has been found in many disease models, and structural deficiency also causes altered matrix assembly.\n                    <jats:styled-content style=\"fixed-case\">SLRP<\/jats:styled-content>\n                    s regulate assembly of the extracellular matrix, which defines the microenvironment, modulating both the extracellular matrix and cellular functions, with an impact on tissue function.\n                  <\/jats:p>","DOI":"10.1111\/febs.12136","type":"journal-article","created":{"date-parts":[[2013,1,19]],"date-time":"2013-01-19T08:26:37Z","timestamp":1358583997000},"page":"2120-2137","source":"Crossref","is-referenced-by-count":377,"title":["The regulatory roles of small leucine\u2010rich proteoglycans in extracellular matrix 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