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To exert these functions, they undergo a series of processing reactions by heparan\u2010sulfate\u2010modifying enzymes (<jats:styled-content style=\"fixed-case\">HSME<\/jats:styled-content>s), which endows them with highly modified heparan sulfate (<jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content>) domains that provide specific docking sites for a large number of bioactive molecules. The development and antigen\u2010dependent differentiation of normal B lymphocytes, as well as the growth and progression of B\u2010lineage malignancies, are orchestrated by an array of growth factors, cytokines and chemokines many of which display <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content> binding. As discussed in this review, tightly regulated <jats:styled-content style=\"fixed-case\">HSPG<\/jats:styled-content> expression is a requirement for normal B cell maturation, differentiation and function. In addition, the <jats:styled-content style=\"fixed-case\">HSPG<\/jats:styled-content> syndecan\u20101 functions as a versatile co\u2010receptor for signals from the bone marrow microenvironment, essential for the survival of long\u2010lived plasma cells and multiple myeloma (<jats:styled-content style=\"fixed-case\">MM<\/jats:styled-content>) plasma cells. Targeting of <jats:styled-content style=\"fixed-case\">HSME<\/jats:styled-content>s or <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content> chains on <jats:styled-content style=\"fixed-case\">MM<\/jats:styled-content> cells increases their sensitivity to drugs currently used in <jats:styled-content style=\"fixed-case\">MM<\/jats:styled-content> treatment, including bortezomib, lenalidomide or dexamethasone. Taken together, these findings render the <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content> biosynthetic machinery a promising target for <jats:styled-content style=\"fixed-case\">MM<\/jats:styled-content> treatment.<\/jats:p>","DOI":"10.1111\/febs.12180","type":"journal-article","created":{"date-parts":[[2013,2,19]],"date-time":"2013-02-19T12:31:28Z","timestamp":1361277088000},"page":"2180-2193","source":"Crossref","is-referenced-by-count":54,"title":["Heparan sulfate proteoglycans in the control of <scp>B<\/scp> cell development and the pathogenesis of multiple myeloma"],"prefix":"10.1111","volume":"280","author":[{"given":"Rogier M.","family":"Reijmers","sequence":"first","affiliation":[{"name":"Department of Pathology Academic Medical Center Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel","family":"Spaargaren","sequence":"additional","affiliation":[{"name":"Department of Pathology Academic Medical Center Amsterdam 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