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A direct link between lumican expression and melanoma progression and metastasis has been demonstrated. Lumican was shown to impede tumour cell migration and invasion by directly interacting with the \u03b1<jats:sub>2<\/jats:sub>\u03b2<jats:sub>1<\/jats:sub> integrin. In addition, an active sequence of the lumican core protein, called lumcorin, was identified as being responsible for inhibition of melanoma cell migration. Lumican was also shown to exert angiostatic properties by downregulating the proteolytic activity associated with endothelial cell membranes, particularly matrix metalloproteinase (<jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>)\u201014 and <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20109. Globally, lumican appears to be a potent agent for inhibiting tumour progression rather than tumorigenesis. However, progressive changes in proteoglycans occur in the tumour environment. The complexity and diversity of proteoglycan structure might be responsible for a variety of functions that regulate cell behaviour. Through their core protein and their glycosaminoglycan chains, proteoglycans can interact with growth factors and chemokines. These interactions affect cell signalling, motility, adhesion, growth, and apoptosis. This review summarizes recent data concerning lumican control of tumour progression in different cancers, with a particular focus on its interactions with <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>s and integrins. Its potential therapeutic implications are discussed.<\/jats:p>","DOI":"10.1111\/febs.12210","type":"journal-article","created":{"date-parts":[[2013,2,25]],"date-time":"2013-02-25T17:17:41Z","timestamp":1361812661000},"page":"2369-2381","source":"Crossref","is-referenced-by-count":100,"title":["Lumican effects in the control of tumour progression and their links with metalloproteinases and integrins"],"prefix":"10.1111","volume":"280","author":[{"given":"St\u00e9phane","family":"Br\u00e9zillon","sequence":"first","affiliation":[{"name":"Laboratoire de Biochimie M\u00e9dicale et de Biologie Mol\u00e9culaire CNRS FRE 3481 Universit\u00e9 de Reims\u2010Champagne\u2010Ardenne Reims France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna","family":"Pietraszek","sequence":"additional","affiliation":[{"name":"Laboratoire de Biochimie M\u00e9dicale et de Biologie Mol\u00e9culaire CNRS FRE 3481 Universit\u00e9 de Reims\u2010Champagne\u2010Ardenne Reims 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