{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T07:02:34Z","timestamp":1791356554273,"version":"4.3.1"},"reference-count":146,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2013,3,28]],"date-time":"2013-03-28T00:00:00Z","timestamp":1364428800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The FEBS Journal"],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:p>The presence of iduronic acid in chondroitin\/dermatan sulfate changes the properties of the polysaccharides because it generates a more flexible chain with increased binding potentials. Iduronic acid in chondroitin\/dermatan sulfate influences multiple cellular properties, such as migration, proliferation, differentiation, angiogenesis and the regulation of cytokine\/growth factor activities. Under pathological conditions such as wound healing, inflammation and cancer, iduronic acid has diverse regulatory functions. Iduronic acid is formed by two epimerases (i.e. dermatan sulfate epimerase 1 and 2) that have different tissue distribution and properties. The role of iduronic acid in chondroitin\/dermatan sulfate is highlighted by the vast changes in connective tissue features in patients with a new type of Ehler\u2013Danlos syndrome: adducted thumb\u2010clubfoot syndrome. Future research aims to understand the roles of the two epimerases and their interplay with the sulfotransferases involved in chondroitin sulfate\/dermatan sulfate biosynthesis. Furthermore, a better definition of chondroitin\/dermatan sulfate functions using different knockout models is needed. In this review, we focus on the two enzymes responsible for iduronic acid formation, as well as the role of iduronic acid in health and disease.<\/jats:p>","DOI":"10.1111\/febs.12214","type":"journal-article","created":{"date-parts":[[2013,2,26]],"date-time":"2013-02-26T19:57:41Z","timestamp":1361908661000},"page":"2431-2446","source":"Crossref","is-referenced-by-count":135,"title":["Biological functions of iduronic acid in chondroitin\/dermatan sulfate"],"prefix":"10.1111","volume":"280","author":[{"given":"Martin A.","family":"Thelin","sequence":"first","affiliation":[{"name":"Department of Experimental Medical Science, BMC Lund University Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Bartolini","sequence":"additional","affiliation":[{"name":"Department of Experimental Medical Science, BMC Lund University Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakob","family":"Axelsson","sequence":"additional","affiliation":[{"name":"Department of Experimental Medical Science, BMC Lund University Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata","family":"Gustafsson","sequence":"additional","affiliation":[{"name":"Department of Experimental Medical Science, BMC Lund University Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emil","family":"Tykesson","sequence":"additional","affiliation":[{"name":"Department of Experimental Medical Science, BMC Lund University Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edgar","family":"Pera","sequence":"additional","affiliation":[{"name":"Department of Experimental Medical Science, BMC Lund University Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c5ke","family":"Oldberg","sequence":"additional","affiliation":[{"name":"Department of Experimental Medical Science, BMC Lund University Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Maccarana","sequence":"additional","affiliation":[{"name":"Department of Experimental Medical Science, BMC Lund University Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Malmstrom","sequence":"additional","affiliation":[{"name":"Department of Experimental Medical Science, BMC Lund University Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,3,28]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1369\/0022155412459857"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.4161\/cib.4.2.14547"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.2174\/157016308786733564"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)43635-0"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0008-6215(90)84164-P"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/glycob\/4.5.685"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj1430379"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj1430369"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/glycob\/cwj027"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellbi.2009.04.018"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-61779-498-8_7"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/glycob\/cwj093"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-11-1351"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.673"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4001190"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M809339200"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.241175798"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0705807105"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M512055200"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.164.5.2565"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M513373200"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/glycob\/cws065"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)41532-9"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/glycob\/cwp110"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.21300"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0945-053X(97)90020-2"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2010.253"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00430-09"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M208442200"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1039\/c1mb05139c"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/glycob\/cwq208"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.34115"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2009.11.010"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.35232"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1021\/pr070446f"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R111.298430"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.088120"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2011.02.019"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.2741\/3637"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2007.05.001"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M510870200"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sbi.2007.08.015"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.1080\/03008200802148546"},{"key":"e_1_2_13_45_1","doi-asserted-by":"publisher","DOI":"10.1093\/glycob\/cwf066"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI4742"},{"key":"e_1_2_13_47_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.43.28116"},{"key":"e_1_2_13_48_1","doi-asserted-by":"publisher","DOI":"10.1097\/BCR.0b013e318240540a"},{"key":"e_1_2_13_49_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M003387200"},{"key":"e_1_2_13_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2011.04401.x"},{"key":"e_1_2_13_51_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi990711d"},{"key":"e_1_2_13_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-4889(90)90005-X"},{"key":"e_1_2_13_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2011.01.031"},{"key":"e_1_2_13_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2011.01.028"},{"key":"e_1_2_13_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9150(98)00107-5"},{"key":"e_1_2_13_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)45469-0"},{"key":"e_1_2_13_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-9084(02)01428-1"},{"key":"e_1_2_13_58_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.111.238659"},{"key":"e_1_2_13_59_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.112.300444"},{"key":"e_1_2_13_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)83708-5"},{"key":"e_1_2_13_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)44747-8"},{"key":"e_1_2_13_62_1","doi-asserted-by":"publisher","DOI":"10.1093\/glycob\/cwj117"},{"key":"e_1_2_13_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1877-1173(10)93015-9"},{"key":"e_1_2_13_64_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-12-127928"},{"key":"e_1_2_13_65_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1614856"},{"key":"e_1_2_13_66_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI11692"},{"key":"e_1_2_13_67_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.2001.02251.x"},{"key":"e_1_2_13_68_1","doi-asserted-by":"publisher","DOI":"10.1002\/pros.10276"},{"key":"e_1_2_13_69_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.29.7499"},{"key":"e_1_2_13_70_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2012.02853.x"},{"key":"e_1_2_13_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1357-2725(02)00264-9"},{"key":"e_1_2_13_72_1","doi-asserted-by":"publisher","DOI":"10.1093\/glycob\/cwp041"},{"key":"e_1_2_13_73_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M806015200"},{"key":"e_1_2_13_74_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.313437"},{"key":"e_1_2_13_75_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M807671200"},{"key":"e_1_2_13_76_1","first-page":"2851","article-title":"Effects of glycosaminoglycans on cell proliferation of normal osteoblasts and human osteosarcoma cells depend on their type and fine chemical compositions","volume":"25","author":"Nikitovic D","year":"2005","journal-title":"Anticancer Res"},{"key":"e_1_2_13_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(01)00884-6"},{"key":"e_1_2_13_78_1","doi-asserted-by":"publisher","DOI":"10.1006\/excr.1993.1124"},{"key":"e_1_2_13_79_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2613.2009.00695.x"},{"key":"e_1_2_13_80_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10555-009-9182-y"},{"key":"e_1_2_13_81_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cr.7290318"},{"key":"e_1_2_13_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0955-0674(02)00375-7"},{"key":"e_1_2_13_83_1","doi-asserted-by":"publisher","DOI":"10.1038\/346281a0"},{"key":"e_1_2_13_84_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj1970483"},{"key":"e_1_2_13_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2012.04.029"},{"key":"e_1_2_13_86_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.4.1342"},{"key":"e_1_2_13_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(20)65145-6"},{"key":"e_1_2_13_88_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj3020527"},{"key":"e_1_2_13_89_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7600615"},{"key":"e_1_2_13_90_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.15.8877"},{"key":"e_1_2_13_91_1","doi-asserted-by":"publisher","DOI":"10.1258\/ebm.2011.011124"},{"key":"e_1_2_13_92_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2012.59"},{"key":"e_1_2_13_93_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI116631"},{"key":"e_1_2_13_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2007.07.001"},{"key":"e_1_2_13_95_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.1997.tb01401.x"},{"key":"e_1_2_13_96_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1025336114352"},{"key":"e_1_2_13_97_1","doi-asserted-by":"publisher","DOI":"10.1038\/1746"},{"key":"e_1_2_13_98_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.30.18709"},{"key":"e_1_2_13_99_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0177(199912)216:4\/5<499::AID-DVDY18>3.0.CO;2-S"},{"key":"e_1_2_13_100_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.12.4044"},{"key":"e_1_2_13_101_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.130.4.1005"},{"key":"e_1_2_13_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)88670-2"},{"key":"e_1_2_13_103_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.335935"},{"key":"e_1_2_13_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2012.03.020"},{"key":"e_1_2_13_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)54494-X"},{"key":"e_1_2_13_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2010.01.016"},{"key":"e_1_2_13_107_1","doi-asserted-by":"publisher","DOI":"10.1038\/35006129"},{"key":"e_1_2_13_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2011.10.001"},{"key":"e_1_2_13_109_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M407241200"},{"key":"e_1_2_13_110_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M403031200"},{"key":"e_1_2_13_111_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7827-4-24"},{"key":"e_1_2_13_112_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0001-6349.2005.00484.x"},{"key":"e_1_2_13_113_1","first-page":"197","article-title":"Expression of syndecan\u20101 and \u20103 during embryogenesis of the central nervous system in relation to binding with midkine","volume":"121","author":"Nakanishi T","year":"1997","journal-title":"J Biochem"},{"key":"e_1_2_13_114_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(199807)185:3<290::AID-PATH91>3.0.CO;2-I"},{"key":"e_1_2_13_115_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1399"},{"key":"e_1_2_13_116_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.017350"},{"key":"e_1_2_13_117_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.027334"},{"key":"e_1_2_13_118_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI10559"},{"key":"e_1_2_13_119_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7827-2-3"},{"key":"e_1_2_13_120_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3023"},{"key":"e_1_2_13_121_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-148X.2011.00929.x"},{"key":"e_1_2_13_122_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1025731428581"},{"key":"e_1_2_13_123_1","doi-asserted-by":"publisher","DOI":"10.1139\/O09-047"},{"key":"e_1_2_13_124_1","doi-asserted-by":"publisher","DOI":"10.1042\/BST20110697"},{"key":"e_1_2_13_125_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12253-011-9461-0"},{"key":"e_1_2_13_126_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M507130200"},{"key":"e_1_2_13_127_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1206763"},{"key":"e_1_2_13_128_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1204119"},{"key":"e_1_2_13_129_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2010.282"},{"key":"e_1_2_13_130_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M801433200"},{"key":"e_1_2_13_131_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-008-9575-8"},{"key":"e_1_2_13_132_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2012.03.022"},{"key":"e_1_2_13_133_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.28.16522"},{"key":"e_1_2_13_134_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10059-009-0069-0"},{"key":"e_1_2_13_135_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90031-0"},{"key":"e_1_2_13_136_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2010.01236.x"},{"key":"e_1_2_13_137_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C000213200"},{"key":"e_1_2_13_138_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5002269"},{"key":"e_1_2_13_139_1","doi-asserted-by":"publisher","DOI":"10.1158\/1541-7786.MCR-07-0200"},{"key":"e_1_2_13_140_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.324988"},{"key":"e_1_2_13_141_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0027922"},{"key":"e_1_2_13_142_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.167.6.3099"},{"key":"e_1_2_13_143_1","first-page":"6084","article-title":"Overexpression of endocan induces tumor formation","volume":"63","author":"Scherpereel A","year":"2003","journal-title":"Cancer Res"},{"key":"e_1_2_13_144_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2006.05.004"},{"key":"e_1_2_13_145_1","first-page":"3364","article-title":"Testican 2 abrogates inhibition of membrane\u2010type matrix metalloproteinases by other testican family proteins","volume":"63","author":"Nakada M","year":"2003","journal-title":"Cancer Res"},{"key":"e_1_2_13_146_1","first-page":"8896","article-title":"Suppression of membrane\u2010type 1 matrix metalloproteinase (MMP)\u2010mediated MMP\u20102 activation and tumor invasion by testican 3 and its splicing variant gene product, N\u2010Tes","volume":"61","author":"Nakada M","year":"2001","journal-title":"Cancer Res"},{"key":"e_1_2_13_147_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1025331929373"}],"container-title":["The FEBS Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ffebs.12214","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/febs.12214","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/febs.12214","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/febs.12214","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T16:26:09Z","timestamp":1694535969000},"score":1,"resource":{"primary":{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/10.1111\/febs.12214"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3,28]]},"references-count":146,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2013,5]]}},"alternative-id":["10.1111\/febs.12214"],"URL":"https:\/\/doi.org\/10.1111\/febs.12214","archive":["Portico"],"relation":{},"ISSN":["1742-464X","1742-4658"],"issn-type":[{"value":"1742-464X","type":"print"},{"value":"1742-4658","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,3,28]]}}}